Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial

This pilot clinical trial investigated the effects of GlyNAC supplementation (a combination of glycine and N-acetylcysteine) in older adults over a 24-week period. The study found that GlyNAC supplementation corrected intracellular glutathione deficiency, reduced oxidative stress, improved mitochondrial function, decreased inflammation, enhanced insulin sensitivity, ameliorated endothelial dysfunction, reduced genomic damage,