This prospective cohort study analyzed data from 25,241 non-exercising adults (mean age 61.8 years) in the UK Biobank to assess the impact of vigorous intermittent lifestyle physical activity (VILPA) on mortality. VILPA, characterized by brief bouts (1–2 minutes) of vigorous activity during daily life, was measured using wearable accelerometers. Over
This commentary discusses a study by Stewart et al. (2016) that examined the effects of acute endurance exercise on cardiac function in recreationally active men. Participants performed two cycling trials: 90 minutes at heavy intensity and 120 minutes at moderate intensity. Findings indicated transient reductions in left and right ventricular
This 2024 study evaluated the accuracy of a compact, disposable pressure monitoring device (Compass™) used during partial REBOA procedures in a swine model. Four Yorkshire pigs underwent induced hemorrhagic shock followed by REBOA with the Compass™ transducer. Mean arterial pressures recorded by the device were compared to standard arterial line
This 2022 extension of the STEP 1 trial assessed the effects of discontinuing semaglutide 2.4 mg weekly in adults with obesity. After 68 weeks of treatment, participants had lost an average of 17.3% of their body weight. One year post-withdrawal, they regained approximately two-thirds of this weight loss, resulting in
This 2024 secondary analysis of a randomized clinical trial examined the effects of exercise, GLP-1 receptor agonist (liraglutide) treatment, and their combination on bone health in adults with obesity. After an initial 8-week low-calorie diet, 195 participants were randomized into four groups: exercise alone, liraglutide alone, combination of both, or
This 2025 study conducted a disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) to identify drugs associated with noninfectious myocarditis. Analyzing data from 2004 to 2024, the researchers found 10,763 reports of noninfectious myocarditis. The top five drugs with the highest reporting odds ratios (RORs) were phendimetrazine tartrate
This 2022 study identified protein tyrosine phosphatase receptor delta (PTPRD) as the neural receptor for asprosin, a fasting-induced hormone derived from white adipose tissue. Asprosin crosses the blood-brain barrier and binds to PTPRD on AgRP neurons in the hypothalamus, activating them to stimulate appetite. Genetic ablation of PTPRD in mice
This 2019 letter addresses concerns raised about the long-term use of phentermine for weight management. The authors acknowledge existing gaps in knowledge regarding the safety and efficacy of extended phentermine use but highlight emerging evidence suggesting its potential benefits. They reference observational studies indicating that prolonged phentermine therapy may lead
The 2023 OASIS 1 trial evaluated the efficacy and safety of oral semaglutide 50 mg daily in 667 adults with overweight or obesity without type 2 diabetes. Over 68 weeks, participants receiving semaglutide experienced a mean weight loss of 15.1%, compared to 2.4% with placebo. Notably, 85% of the semaglutide
This 2019 review article explores hydrolyzed collagen (HC), a group of peptides with low molecular weight (3–6 kDa) obtained through enzymatic hydrolysis in acidic or alkaline media. HC can be extracted from various sources, including bovine, porcine, and marine origins. Marine-derived HC, particularly from fish skin, scales, and bones, has
This 2020 review examines the impact of high-protein diets on kidney function and longevity. High dietary protein intake can cause intraglomerular hypertension, leading to kidney hyperfiltration, glomerular injury, and proteinuria. While high-protein diets are popular for weight loss and type 2 diabetes management, evidence suggests that they may worsen renal
This 2007 review examines the metabolic impacts of high-protein diets, particularly in weight-stable individuals. Findings indicate that higher protein intake is associated with lower blood pressure and, in diabetic patients, reduced glycosylated hemoglobin levels. However, the long-term effects on atherosclerosis risk remain unclear due to limited and conflicting epidemiological data.