Well Referenced

Tag: mitochondrial function

Emerging Anti-Aging Strategies – Scientific Basis and Efficacy

This comprehensive review examines the scientific foundations and efficacy of emerging anti-aging strategies aimed at promoting healthier aging and mitigating age-related diseases. Key interventions discussed include caloric restriction, intermittent fasting, senolytics, sirtuin-activating compounds, NAD+ precursors, and stem cell therapies. The review highlights the mechanisms by which these strategies influence aging

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June 26, 2025 No Comments

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

This 2011 randomized, double-blind, placebo-controlled crossover study examined the effects of 150 mg/day resveratrol supplementation over 30 days in 11 healthy obese men. Resveratrol significantly reduced sleeping and resting metabolic rates. In skeletal muscle, it activated AMPK, increased SIRT1 and PGC-1α protein levels, and enhanced mitochondrial respiration on fatty acid-derived

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June 26, 2025 No Comments

Melatonin and brain inflammaging

This 2015 review explores melatonin’s multifaceted role in mitigating brain inflammaging—a chronic, low-grade inflammation contributing to aging and neurodegeneration. Melatonin functions as a direct and indirect antioxidant, modulates mitochondrial function, and suppresses proinflammatory pathways by inhibiting NADPH oxidase, inducible nitric oxide synthase, and proinflammatory cytokines. It also enhances circadian rhythm

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June 26, 2025 No Comments

Alpha-Lipoic Acid as a New Treatment Option for Alzheimer’s Disease—A 48 Months Follow-Up Analysis

This open-label study evaluated the long-term effects of daily 600 mg alpha-lipoic acid (ALA) supplementation in 43 patients with mild to moderate Alzheimer’s disease (AD) over a 48-month period. All participants were concurrently receiving standard acetylcholinesterase inhibitor therapy. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the

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June 26, 2025 No Comments

L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain

This review article examines the neuroprotective roles of L-carnitine and its acetylated derivative, acetyl-L-carnitine (ALCAR), in the developing brain. L-carnitine facilitates the transport of long-chain fatty acids into mitochondria for β-oxidation, crucial for energy production. ALCAR, capable of crossing the blood-brain barrier, provides acetyl groups for acetylcholine synthesis and supports

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June 26, 2025 No Comments

3,5-Diiodothyronine: A Novel Thyroid Hormone Metabolite and Potent Modulator of Energy Metabolism

This review explores the metabolic effects of 3,5-diiodo-L-thyronine (3,5-T2), an endogenous thyroid hormone metabolite. In rodent models, exogenous 3,5-T2 administration rapidly increases resting metabolic rate and induces beneficial hypolipidemic effects. The mechanisms are primarily non-genomic, targeting mitochondria to enhance oxidative phosphorylation and fatty acid oxidation. While some thyroid hormone receptor-mediated

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June 26, 2025 No Comments

Neurochemical effects of the R form of α-lipoic acid and its neuroprotective mechanism in cellular models of Parkinson’s disease

This 2017 study investigated the neuroprotective effects of R-α-lipoic acid (RLA) in cellular models of Parkinson’s disease (PD) induced by 6-hydroxydopamine (6-OHDA) and MPTP. RLA treatment enhanced cell viability, reduced apoptosis, and decreased intracellular reactive oxygen species (ROS) levels. It also restored dopamine levels and reduced α-synuclein accumulation. Additionally, RLA

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June 26, 2025 No Comments

Randomized controlled trial of sulforaphane and metabolite discovery in children with Autism Spectrum Disorder

This 36-week Phase II randomized, double-blind, placebo-controlled trial evaluated the safety, tolerability, and efficacy of sulforaphane (SF) in 57 children aged 3–12 years with autism spectrum disorder (ASD). Participants received either SF (derived from broccoli seed and sprout extract tablets containing glucoraphanin and active myrosinase, yielding approximately 15 µmol SF

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June 26, 2025 No Comments

Melatonin and cancer: From the promotion of genomic stability to use in cancer treatment

This 2019 review explores melatonin’s multifaceted role in cancer prevention and therapy. Melatonin acts as a potent antioxidant, directly scavenging free radicals and enhancing the activity of antioxidant enzymes, thereby mitigating oxidative stress. It regulates mitochondrial function and inhibits pro-oxidant enzymes, contributing to the maintenance of genomic stability. Melatonin also

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June 26, 2025 No Comments