Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression

This 2024 animal study evaluated the antidepressant-like effects of repeated cannabidiol (CBD) treatment in Flinders Sensitive Line (FSL) rats, a genetic model of depression. Rats treated with CBD (10 mg/kg intraperitoneally for 7 days) showed reduced depressive-like behaviors in the Forced Swimming Test without changes in locomotor activity. CBD enhanced