This study investigates the antidepressant-like effects of cannabidiol (CBD) in mice, highlighting its role in serotonin modulation. Administering 10 mg/kg of CBD induced significant antidepressant effects in the forced swim test (FST), comparable to fluoxetine (10 mg/kg) and desipramine (5 mg/kg). Lower doses of CBD (7 mg/kg) combined with sub-effective
This study examines the antidepressant-like effects of cannabidiol (CBD) in mice, demonstrating that a dose of 30 mg/kg significantly reduced immobility in the forced swimming test, an effect comparable to the standard antidepressant imipramine. The study suggests that CBD’s effects are mediated through 5-HT1A receptor activation, as they were blocked
This 2024 animal study evaluated the antidepressant-like effects of repeated cannabidiol (CBD) treatment in Flinders Sensitive Line (FSL) rats, a genetic model of depression. Rats treated with CBD (10 mg/kg intraperitoneally for 7 days) showed reduced depressive-like behaviors in the Forced Swimming Test without changes in locomotor activity. CBD enhanced
