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Tag: CBD

Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

This systematic review explores the broad therapeutic potential of cannabidiol (CBD) in the treatment of psychiatric disorders such as anxiety, depression, and psychosis. It synthesizes data from multiple in vivo studies and highlights that CBD exerts its beneficial effects through several mechanisms, including facilitating 5-HT1A receptor-mediated neurotransmission, potentiating anandamide-mediated pathways

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June 26, 2025 No Comments

New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect

This 2024 review investigates the antidepressant mechanisms of cannabidiol (CBD), focusing on its interaction with serotonin and BDNF-TrkB signaling pathways. CBD may exert rapid and sustained antidepressant effects by increasing serotonin release in the prefrontal cortex via action on dorsal raphe nuclei and enhancing BDNF-TrkB signaling, which promotes neuroplasticity. These

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June 26, 2025 No Comments

Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression

This 2024 animal study evaluated the antidepressant-like effects of repeated cannabidiol (CBD) treatment in Flinders Sensitive Line (FSL) rats, a genetic model of depression. Rats treated with CBD (10 mg/kg intraperitoneally for 7 days) showed reduced depressive-like behaviors in the Forced Swimming Test without changes in locomotor activity. CBD enhanced

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June 26, 2025 No Comments

Cannabidiol for the Treatment of Brain Disorders: Therapeutic Potential and Routes of Administration

This study explores the therapeutic potential of cannabidiol (CBD) for brain disorders, focusing on its interaction with multiple brain targets and evaluating alternative drug delivery methods to enhance its efficacy. Oral CBD administration is limited by slow absorption and low bioavailability due to first-pass metabolism, prompting interest in alternative delivery

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June 26, 2025 No Comments

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

This study examined the antidepressant-like effects of cannabidiol (CBD) in rodent models, demonstrating that a single dose (7-30 mg/kg) produced rapid and sustained reductions in depressive-like behaviors. The effects were associated with increased expression of synaptic proteins (synaptophysin and PSD95), elevated brain-derived neurotrophic factor (BDNF) levels, and enhanced spine density

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June 26, 2025 No Comments

Chronic administration of synthetic cannabidiol induces antidepressant effects involving modulation of serotonin and noradrenaline levels in the hippocampus

This study examined the antidepressant-like effects of chronic administration of synthetic cannabidiol (CBD) in mice. Over seven days, mice received CBD at doses of 10, 30, or 100 mg/kg, and depressive-like behaviors were assessed using the forced swim test (FST). The study found that 100 mg/kg of CBD significantly reduced

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June 26, 2025 No Comments

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

This review examines preclinical studies on cannabidiol (CBD) and its potential antidepressant effects, focusing on molecular mechanisms and interactions with neurotransmitter systems such as serotonergic, glutamatergic, and endocannabinoid pathways. CBD has been shown to enhance brain-derived neurotrophic factor (BDNF) signaling, promote synaptogenesis in the medial prefrontal cortex, and support neurogenesis

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June 26, 2025 No Comments