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Tag: neuroplasticity

n-3 Fatty Acids: Role in Neurogenesis and Neuroplasticity

This 2013 review outlines the neurobiological roles of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), and alpha-linolenic acid (ALA), in promoting adult neurogenesis and synaptic plasticity. These omega-3 fatty acids support brain function through antioxidant, anti-inflammatory, and anti-apoptotic actions. They enhance neurogenesis in the hippocampal

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June 26, 2025 No Comments

Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders-An Overview of Experimental Evidence

This review examines the dual effects of resveratrol on anxiety and stress disorders, highlighting its potential to alleviate anxiety through mechanisms such as antioxidant activity, mitochondrial function enhancement, and neuroplasticity improvement. However, it also emphasizes that under certain conditions, resveratrol may exacerbate anxiety symptoms, suggesting a need for careful dosage

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June 26, 2025 No Comments

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

This review examines preclinical studies on cannabidiol (CBD) and its potential antidepressant effects, focusing on molecular mechanisms and interactions with neurotransmitter systems such as serotonergic, glutamatergic, and endocannabinoid pathways. CBD has been shown to enhance brain-derived neurotrophic factor (BDNF) signaling, promote synaptogenesis in the medial prefrontal cortex, and support neurogenesis

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June 26, 2025 No Comments

New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect

This 2024 review investigates the antidepressant mechanisms of cannabidiol (CBD), focusing on its interaction with serotonin and BDNF-TrkB signaling pathways. CBD may exert rapid and sustained antidepressant effects by increasing serotonin release in the prefrontal cortex via action on dorsal raphe nuclei and enhancing BDNF-TrkB signaling, which promotes neuroplasticity. These

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June 26, 2025 No Comments

Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression

This 2024 animal study evaluated the antidepressant-like effects of repeated cannabidiol (CBD) treatment in Flinders Sensitive Line (FSL) rats, a genetic model of depression. Rats treated with CBD (10 mg/kg intraperitoneally for 7 days) showed reduced depressive-like behaviors in the Forced Swimming Test without changes in locomotor activity. CBD enhanced

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June 26, 2025 No Comments

Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations

This study explores the role of pregnenolone sulfate (PREG-S) in cognitive functions, particularly its effects on aging and memory impairment. The research shows that PREG-S improves cognitive performance in aging rats by increasing acetylcholine release, enhancing paradoxical sleep, and promoting neurogenesis in the hippocampus, which are crucial for memory processes.

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June 26, 2025 No Comments

Systematic Review and Dosage Analysis: Hyperbaric Oxygen Therapy Efficacy in Mild Traumatic Brain Injury Persistent Postconcussion Syndrome

This systematic review analyzed the efficacy of hyperbaric oxygen therapy (HBOT) in treating persistent postconcussion syndrome (PPCS) following mild traumatic brain injury (mTBI). The findings showed significant improvements in cognitive function, memory, attention, and overall quality of life in affected individuals. The most effective HBOT dosing protocol identified was 1.5

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June 26, 2025 No Comments