Well Referenced

Tag: prefrontal cortex

New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol’s antidepressant effect

This 2024 review investigates the antidepressant mechanisms of cannabidiol (CBD), focusing on its interaction with serotonin and BDNF-TrkB signaling pathways. CBD may exert rapid and sustained antidepressant effects by increasing serotonin release in the prefrontal cortex via action on dorsal raphe nuclei and enhancing BDNF-TrkB signaling, which promotes neuroplasticity. These

Read More »
June 26, 2025 No Comments

Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression

This 2024 animal study evaluated the antidepressant-like effects of repeated cannabidiol (CBD) treatment in Flinders Sensitive Line (FSL) rats, a genetic model of depression. Rats treated with CBD (10 mg/kg intraperitoneally for 7 days) showed reduced depressive-like behaviors in the Forced Swimming Test without changes in locomotor activity. CBD enhanced

Read More »
June 26, 2025 No Comments

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex

This study examined the antidepressant-like effects of cannabidiol (CBD) in rodent models, demonstrating that a single dose (7-30 mg/kg) produced rapid and sustained reductions in depressive-like behaviors. The effects were associated with increased expression of synaptic proteins (synaptophysin and PSD95), elevated brain-derived neurotrophic factor (BDNF) levels, and enhanced spine density

Read More »
June 26, 2025 No Comments

Extinction memory improvement by the metabolic enhancer methylene blue

This animal study examined the effects of methylene blue (MB), a metabolic enhancer, on extinction memory retention in rats. Results showed that MB-treated rats exhibited significantly lower freezing behavior in response to the conditioned stimulus, indicating improved retention of extinction memory. Additionally, MB increased brain cytochrome oxidase activity by 38%,

Read More »
June 26, 2025 No Comments

Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys

The study titled “Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys” (Journal of Neuroscience, 2003, PMID: 12843274) is an observational study investigating the effects of cyclic estrogen replacement on cognitive abilities in aged female rhesus monkeys following ovariectomy. Results showed significant improvements in cognitive tasks related to

Read More »
June 26, 2025 No Comments