This 2020 study investigated taurine’s antiallergic effects on allergic rhinitis (AR) through both in vitro and in vivo models. In AR patients, serum levels of extracellular superoxide dismutase (SOD3) were reduced. Taurine treatment increased SOD3 expression in human mast cells via activation of peroxisome proliferator-activated receptor-γ (PPAR-γ), leading to decreased
This 2014 study investigates the differential sensitivity of non-small cell lung cancer (NSCLC) cell lines to lunasin, a soy-derived peptide with anticancer properties. The research compares lunasin-sensitive H661 cells to resistant H1299 cells, revealing that lunasin internalization is higher in H661 cells. Lunasin interacts with integrins containing αv, α5, β1,
This prospective single-arm “window of opportunity” trial evaluated the biological effects of short-term metformin administration in 39 non-diabetic women with early-stage breast cancer. Patients received 500 mg of metformin three times daily for at least two weeks between diagnostic biopsy and surgery. Metformin treatment led to significant reductions in tumor
This 2024 animal study evaluated the antidepressant-like effects of repeated cannabidiol (CBD) treatment in Flinders Sensitive Line (FSL) rats, a genetic model of depression. Rats treated with CBD (10 mg/kg intraperitoneally for 7 days) showed reduced depressive-like behaviors in the Forced Swimming Test without changes in locomotor activity. CBD enhanced
