The meta-analysis titled "Dehydroepiandrosterone (DHEA) supplementation for depression: a systematic review and meta-analysis" (Psychoneuroendocrinology, 2018, PMID: 30124161) examined the efficacy of DHEA supplementation for reducing depressive symptoms across multiple randomized controlled trials. The findings indicated that DHEA supplementation demonstrated a moderate antidepressant effect and was generally well-tolerated, though mild side
