Well Referenced

Tag: Randomized Controlled Trials

The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials

This 2020 systematic review and meta-analysis evaluated the effects of berberine supplementation on obesity-related parameters, inflammation, and liver function enzymes. Analyzing 12 randomized controlled trials, the study found that berberine intake led to significant reductions in body weight (mean difference: -2.07 kg), body mass index (BMI), waist circumference, and C-reactive

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June 26, 2025 No Comments

The Effect of Extracorporeal Shock Wave Therapy on Pain Intensity and Neck Disability for Patients With Myofascial Pain Syndrome in the Neck and Shoulder: A Meta-Analysis of Randomized Controlled Trials

This 2021 meta-analysis evaluated the efficacy of extracorporeal shock wave therapy (ESWT) in treating myofascial pain syndrome (MPS) of the neck and shoulder. Analyzing 11 randomized controlled trials, the study found that ESWT significantly improved pain intensity (SMD = 0.67; 95% CI: 0.11 to 1.23; P = 0.02) and pressure

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June 26, 2025 No Comments

Extracorporeal Shock Wave Therapy for the Treatment of Osteoarthritis: A Systematic Review and Meta-Analysis

This 2020 systematic review and meta-analysis evaluated the efficacy and safety of extracorporeal shock wave therapy (ESWT) in treating osteoarthritis (OA). The analysis included randomized controlled trials comparing ESWT with other treatments such as placebo, corticosteroids, hyaluronic acid, medications, ultrasound, kinesiotherapy, moxibustion, acupotomy surgery, platelet-rich plasma, fumigation, and manipulation. ESWT

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June 26, 2025 No Comments

Azelaic Acid Versus Hydroquinone for Managing Patients With Melasma: Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review and meta-analysis evaluated the efficacy and safety of azelaic acid compared to hydroquinone in treating melasma. Analyzing six randomized controlled trials encompassing 673 patients, the study found that azelaic acid led to a greater reduction in the Melasma Area and Severity Index (MASI) scores than hydroquinone (mean

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June 26, 2025 No Comments

Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials

This systematic review evaluates the efficacy and safety of topical tretinoin in treating photoaging by analyzing seven randomized controlled trials. The studies included predominantly female participants and utilized tretinoin concentrations ranging from 0.025% to 5%, with treatment durations between 3 to 24 months. Results consistently demonstrated significant improvements in clinical

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June 26, 2025 No Comments

Shock-wave therapy versus corticosteroid injection on lateral epicondylitis: a meta-analysis of randomized controlled trials

This 2019 meta-analysis evaluated the efficacy of extracorporeal shock wave therapy (ESWT) compared to corticosteroid (CS) injections in treating lateral epicondylitis (LE). Analyzing four randomized controlled trials, the study found that ESWT significantly improved pain intensity (VAS) and grip strength over CS injections at follow-ups beyond 12 weeks. Specifically, ESWT

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June 26, 2025 No Comments

Oxygen-Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials

This 2020 systematic review analyzed 11 randomized controlled trials involving 858 patients to assess the efficacy and safety of intra-articular oxygen-ozone therapy (OOT) for knee osteoarthritis (KOA). The studies compared OOT with various treatments, including placebo, hyaluronic acid, corticosteroids, platelet-rich plasma, hypertonic dextrose, radiofrequency, and celecoxib plus glucosamine. While OOT

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June 26, 2025 No Comments

Ozone Therapy in Knee Osteoarthritis: A Systematic Review

This 2018 systematic review analyzed six randomized controlled trials assessing the efficacy of ozone therapy in knee osteoarthritis (KOA). The studies primarily involved elderly patients with mild to moderate KOA. Findings indicated that ozone therapy provided short-term pain relief, particularly when combined with hyaluronic acid, but was not superior to

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June 26, 2025 No Comments