Well Referenced

Tag: mood disorders

Zinc Monotherapy Increases Serum Brain-Derived Neurotrophic Factor (BDNF) Levels and Decreases Depressive Symptoms in Overweight or Obese Subjects: A Double-Blind, Randomized, Placebo-Controlled Trial

This 2015 double-blind, randomized, placebo-controlled trial investigated the effects of zinc monotherapy on depressive symptoms and serum BDNF levels in overweight or obese individuals. Fifty participants were randomized to receive either 30 mg of elemental zinc daily or a placebo for 12 weeks. The study found that zinc supplementation significantly

Read More »
June 26, 2025 No Comments

Association of Depression and Anxiety Disorders With Autoimmune Thyroiditis: A Systematic Review and Meta-analysis

This 2018 systematic review and meta-analysis evaluated the link between autoimmune thyroiditis (AIT) and mood disorders, specifically depression and anxiety. The analysis included 19 studies comprising over 36,000 individuals. Results showed that patients with AIT, including Hashimoto’s thyroiditis, had a 3.56-fold increased odds of depression and a 2.32-fold increased odds

Read More »
June 26, 2025 No Comments

Depressive Symptoms in Patients with Subclinical Hypothyroidism—The Effect of Treatment with Levothyroxine: A Double-Blind Randomized Clinical Trial

This 2015 double-blind, randomized, placebo-controlled trial assessed whether levothyroxine treatment improves depressive symptoms in 60 adults with subclinical hypothyroidism. Participants were assigned to receive either levothyroxine or placebo for 12 weeks. Depression levels were measured using the Beck Depression Inventory (BDI), which includes somatic and affective subscales. The levothyroxine group

Read More »
June 26, 2025 No Comments

TSH Cut-Off Point Based on Depression in Hypothyroid Patients

This 2017 cross-sectional study investigated the association between thyroid-stimulating hormone (TSH) levels and depression in 174 hypothyroid patients on stable levothyroxine therapy with TSH values ranging from 0.5 to 5 mIU/L. Depression severity was measured using the Beck Depression Inventory (BDI). Receiver operating characteristic (ROC) curve analysis identified a TSH

Read More »
June 26, 2025 No Comments

Growth hormone-releasing hormone and its analogues in health and disease

This review explores the diverse biological effects of growth hormone-releasing hormone (GHRH) and its analogues, highlighting their potential therapeutic applications across various medical conditions. GHRH and its analogues stimulate cell growth, tissue repair, and wound healing, regulate apoptosis, modulate inflammation and immune responses, and offer neuroprotective effects, making them promising

Read More »
June 26, 2025 No Comments

Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy

This review explores the therapeutic potential of Rhodiola rosea, highlighting its adaptogenic properties, including stress management, cognitive enhancement, and mood regulation. Rhodiola has demonstrated benefits for conditions like fatigue, anxiety, and mild depression through its effects on the HPA axis, protein kinases, nitric oxide pathways, and heat shock proteins. Clinical

Read More »
June 26, 2025 No Comments

Efficacy and Safety of Oral Magnesium Supplementation in the Treatment of Depression in the Elderly With Type 2 Diabetes: A Randomized, Equivalent Trial

This 2008 randomized controlled trial evaluated the effectiveness of oral magnesium supplementation versus imipramine in treating depression among elderly patients with type 2 diabetes. The study found that magnesium was equally effective as imipramine in improving depression scores, while offering a more favorable side effect profile. Magnesium’s role in neurotransmitter

Read More »
June 26, 2025 No Comments

Essential elements in depression and anxiety. Part I

This 2014 review article explores the roles of essential elements—zinc, magnesium, lithium, iron, calcium, and chromium—in the development and treatment of depression and anxiety. It highlights evidence from preclinical and clinical studies linking deficiencies in these elements to mood disorders and notes that supplementation may improve the efficacy of antidepressants

Read More »
June 26, 2025 No Comments

Evaluating the Effect of Magnesium and Magnesium Plus Vitamin B6 Supplement on the Severity of Premenstrual Syndrome

This randomized controlled trial investigated the effects of magnesium alone and in combination with vitamin B6 on premenstrual syndrome (PMS) severity in women attending health centers in Isfahan, Iran. After a two-month PMS symptom tracking phase, participants were randomized to receive either magnesium, magnesium plus vitamin B6, or a placebo

Read More »
June 26, 2025 No Comments