Well Referenced

Tag: DHEA

Relationship between androgen deficiency and memory impairment in aging and Alzheimer’s disease

This review explores the association between androgen deficiency—specifically reductions in testosterone (T), dehydroepiandrosterone (DHEA), and its sulfate (DHEA-S)—and memory impairment in aging and Alzheimer’s disease (AD). It highlights that hypoandrogenism correlates with cognitive decline, potentially due to its influence on tau protein hyperphosphorylation, a hallmark of AD pathology. While animal

Read More »
June 26, 2025 No Comments

Intracrinology-Revisited and Prostate Cancer

This 2020 review revisits the concept of intracrinology—the local synthesis of steroid hormones within peripheral tissues—and its significance in prostate cancer, particularly castration-resistant prostate cancer (CRPC). The study elucidates how adrenal precursors like dehydroepiandrosterone (DHEA) and DHEA-sulfate are converted into potent androgens, testosterone (T) and 5α-dihydrotestosterone (5α-DHT), within prostate tissue.

Read More »
June 26, 2025 No Comments

Androgen therapy in women: for whom and when

This 2013 review discusses the clinical use of androgen therapy in women, particularly for those experiencing hypoactive sexual desire disorder (HSDD). It highlights the role of androgens in sexual function, behavior, and cognition, noting that adrenal androgens may influence sexual symptoms and cognitive function in postmenopausal women. The article emphasizes

Read More »
June 26, 2025 No Comments

Reversal of epigenetic aging and immunosenescent trends in humans

The TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) trial examined the effects of a one-year intervention using recombinant human growth hormone (rhGH), dehydroepiandrosterone (DHEA), and metformin on epigenetic aging and immune system function in nine healthy men aged 51–65. The study demonstrated a significant reversal in biological age by an

Read More »
June 26, 2025 No Comments

Role of DHEA in cardiovascular diseases

The article “Role of DHEA in cardiovascular diseases” (pubmed.ncbi.nlm.nih.gov) explores the potential of dehydroepiandrosterone (DHEA) as a therapeutic agent in cardiovascular conditions such as hypertension, coronary artery disease, atherosclerosis, and pulmonary hypertension. DHEA demonstrates anti-remodeling and vasorelaxant properties, mediated through membrane and nuclear receptors, ion channels, calcium signaling, and pathways

Read More »
June 26, 2025 No Comments

Effects of DHEA on metabolic and endocrine functions of adipose tissue

The article “Effects of DHEA on metabolic and endocrine functions of adipose tissue” explores the role of dehydroepiandrosterone (DHEA), a steroid hormone precursor to androgens and estrogens, in regulating fat tissue metabolism. The study examines how DHEA influences lipid metabolism, insulin sensitivity, and adipokine secretion, which are critical in energy

Read More »
June 26, 2025 No Comments

Influence of DHEA administration on 24-hour cortisol concentrations

A single-blind, placebo-controlled crossover study examined the effects of dehydroepiandrosterone (DHEA) administration on 24-hour plasma cortisol levels in healthy older adults. Participants received either a placebo or 200 mg of oral DHEA daily for 15 days. The study found that DHEA administration significantly reduced plasma cortisol concentrations, with a more

Read More »
June 26, 2025 No Comments

Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren’s syndrome; supplementation with dehydroepiandrosterone restores the concentrations

The study “Low serum levels of sex steroids are associated with disease characteristics in primary Sjögren’s syndrome; supplementation with dehydroepiandrosterone restores the concentrations” investigated the impact of dehydroepiandrosterone (DHEA) supplementation on sex hormone levels and disease symptoms in postmenopausal women with primary Sjögren’s syndrome (pSS). In this randomized, placebo-controlled, 9-month

Read More »
June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study

The randomized controlled trial titled “Dehydroepiandrosterone supplementation enhances immune function in HIV-positive subjects with undetectable viral load” (Clinical Infectious Diseases, 2007, PMID: 17263636) investigated whether supplementation with dehydroepiandrosterone (DHEA) could influence HIV replication and immune function. The study found that DHEA did not significantly alter viral load or CD4+ T-cell

Read More »
June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis

The meta-analysis titled “Dehydroepiandrosterone (DHEA) supplementation for depression: a systematic review and meta-analysis” (Psychoneuroendocrinology, 2018, PMID: 30124161) examined the efficacy of DHEA supplementation for reducing depressive symptoms across multiple randomized controlled trials. The findings indicated that DHEA supplementation demonstrated a moderate antidepressant effect and was generally well-tolerated, though mild side

Read More »
June 26, 2025 No Comments