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Tag: neurosteroid

The neurosteroid pregnenolone promotes degradation of key proteins in the innate immune signaling to suppress inflammation

The study investigated the neurosteroid pregnenolone and its ability to suppress inflammation by inducing ubiquitination and degradation of TIRAP and TLR2 in macrophages and microglial cells. This action led to decreased pro-inflammatory cytokine secretion, including tumor necrosis factor α and interleukin-6, through TLR2 and TLR4 pathways. Pregnenolone was also found

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June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis

The meta-analysis titled “Dehydroepiandrosterone (DHEA) supplementation for depression: a systematic review and meta-analysis” (Psychoneuroendocrinology, 2018, PMID: 30124161) examined the efficacy of DHEA supplementation for reducing depressive symptoms across multiple randomized controlled trials. The findings indicated that DHEA supplementation demonstrated a moderate antidepressant effect and was generally well-tolerated, though mild side

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June 26, 2025 No Comments

Dehydroepiandrosterone (DHEA) supplementation for cognitive function

The systematic review titled “Dehydroepiandrosterone (DHEA) supplementation for cognitive function in healthy elderly individuals” (Cochrane Database of Systematic Reviews, 2001, DOI: 10.1002/14651858.CD000304) analyzed data from three randomized controlled trials with a total of 145 healthy participants aged 55 and older. The review found no significant cognitive benefits from DHEA supplementation

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June 26, 2025 No Comments