Well Referenced

Tag: ozone therapy

Ozone therapy in COVID-19: A narrative review

This 2021 narrative review titled “Ozone therapy in COVID-19: A narrative review” (Virus Research, DOI: [10.1016/j.virusres.2020.198207*) assessed the potential role of ozone therapy as an adjunctive treatment for COVID-19. The authors discussed how ozone’s antiviral, anti-inflammatory, immunomodulatory, and oxygenation-enhancing properties could theoretically target key pathophysiological processes like cytokine storms and

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June 26, 2025 No Comments

Therapeutic effects of topical application of ozone on acute cutaneous wound healing

This 2009 animal study titled “Therapeutic Effects of Topical Application of Ozone on Acute Cutaneous Wound Healing” (Journal of Korean Medical Science, DOI: [10.3346/jkms.2009.24.3.368*) evaluated the effects of ozonated olive oil on wound healing in guinea pigs. The ozone-treated group showed significantly smaller wound sizes, increased collagen deposition, greater fibroblast

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June 26, 2025 No Comments

An integrative approach in the treatment of chronic obstructive pulmonary disease: The role of the ozone therapy

This pilot study evaluated the effects of ozonated autohemotherapy as an adjunct to standard medication in the treatment of chronic obstructive pulmonary disease (COPD). Fifty patients with COPD were treated with their usual medications and either ozonated autohemotherapy or standard therapy alone. Results showed that the combination of ozone therapy

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June 26, 2025 No Comments

Indications and efficacy of O2-O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients

This study compared the efficacy of O2-O3 intradiscal injections with steroid intraforaminal injections in the treatment of chronic disc-related pain, involving 517 patients with conditions like herniated discs and degenerative disc disease. The results showed that O2-O3 therapy was more effective in reducing pain and improving functionality, with a 70%

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June 26, 2025 No Comments

Ozone therapy in musculoskeletal medicine: a comprehensive review

This 2024 comprehensive review titled “Ozone therapy in musculoskeletal medicine: a comprehensive review” (European Journal of Medical Research, DOI: [10.1186/s40001-024-01976-4*) evaluated the use of ozone therapy in treating musculoskeletal conditions such as osteoarthritis, lumbar disc herniation, tendinopathies, and myofascial pain syndromes. The review described ozone’s mechanisms—enhancing oxygen metabolism, modulating oxidative

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June 26, 2025 No Comments

Therapeutic relevance of ozone therapy in degenerative diseases: Focus on diabetes and spinal pain

This 2017 narrative review titled “Therapeutic Relevance of Ozone Therapy in Degenerative Diseases: Focus on Diabetes and Spinal Pain” (Journal of Cellular Physiology, DOI: [10.1002/jcp.26044]*) critically examined how controlled, low-dose ozone therapy activates key molecular pathways including HIF-1α, NFAT, Nrf2-ARE, and AP-1, leading to upregulation of antioxidant defenses, modulation of

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June 26, 2025 No Comments

Anti-inflammatory effects of ozonated water in an experimental mouse model

This study evaluated the anti-inflammatory effects of ozonated water in a mouse model of acute inflammation induced by lipopolysaccharide (LPS). The results showed that intraperitoneal injection of ozonated water significantly decreased tumor necrosis factor-α (TNF-α) levels and increased superoxide dismutase (SOD) activity, suggesting its potential as an anti-inflammatory agent. Ozonated

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June 26, 2025 No Comments

Intradiscal O2O3: Rationale, Injection Technique, Short- and Long-term Outcomes for the Treatment of Low Back Pain Due to Disc Herniation

This article examines the use of intradiscal oxygen-ozone (O2O3) therapy for treating low back pain (LBP) caused by disc herniation, particularly in cases that do not respond to conservative treatments. It highlights the safety and efficacy of O2O3 therapy, which reduces disc volume through dehydration and offers significant pain relief

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June 26, 2025 No Comments

Ozone therapy: A clinical review

This 2011 clinical review titled “Ozone therapy: A clinical review” (Journal of Natural Science, Biology and Medicine, DOI: [10.4103/0976-9668.82319*) explored the historical development, mechanisms, delivery methods, and broad therapeutic potential of ozone therapy. It highlighted ozone’s ability to inactivate bacteria, viruses, fungi, and protozoa; stimulate oxygen metabolism; and activate the

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June 26, 2025 No Comments