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Tag: ozone therapy

Efficacy of combined ozone and platelet-rich-plasma treatment versus platelet-rich-plasma treatment alone in early stage knee osteoarthritis

This 2019 retrospective study compared the outcomes of intra-articular platelet-rich plasma (PRP) injections alone versus PRP combined with ozone therapy in patients with early-stage knee osteoarthritis (KOA). The study included 80 patients—45 received PRP alone, and 35 received PRP plus ozone. Both groups exhibited significant improvements in pain (VAS) and

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June 26, 2025 No Comments

The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial

This 2021 randomized clinical trial evaluated the short- and long-term efficacy of intra-articular injections of PRP, PRGF, HA, and ozone in 200 patients with mild to moderate knee osteoarthritis. Patients were randomized into four groups: PRP (2 doses, 3-week interval), PRGF (2 doses, 3-week interval), HA (3 weekly doses), and

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June 26, 2025 No Comments

Ozone Therapy in Knee Osteoarthritis: A Systematic Review

This 2018 systematic review analyzed six randomized controlled trials assessing the efficacy of ozone therapy in knee osteoarthritis (KOA). The studies primarily involved elderly patients with mild to moderate KOA. Findings indicated that ozone therapy provided short-term pain relief, particularly when combined with hyaluronic acid, but was not superior to

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June 26, 2025 No Comments

Detection of chlorite, chlorate and perchlorate in ozonated saline

This 2020 study by Ma et al. investigated the formation of potentially harmful byproducts—chlorite, chlorate, and perchlorate—when ozone is introduced into normal saline, a practice used in certain ozone therapies. Utilizing ion chromatography-mass spectrometry (IC-MS), the researchers analyzed ozonated saline stored in two types of containers: polypropylene saline bottles and

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June 26, 2025 No Comments

Brain ischemia and hypometabolism treated by ozone therapy

This 2011 study evaluated the therapeutic potential of ozone therapy in patients with chronic cerebral ischemia and hypometabolism. Using FDG-PET imaging, researchers demonstrated that ozone therapy significantly improved cerebral glucose metabolism and neurological function. Mechanisms of benefit included enhanced oxygen delivery, improved redox homeostasis, and activation of antioxidant systems. Patients

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June 26, 2025 No Comments

Ozone Therapy for Tumor Oxygenation: a Pilot Study

This 2004 pilot study evaluated the impact of systemic ozone therapy on tumor oxygenation in 18 patients with advanced cancers. Administered via autohemotransfusion over one week, ozone therapy did not significantly alter overall tumor oxygenation levels. However, it notably reduced the proportion of severely hypoxic tumor regions (pO₂ ≤10 mmHg

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June 26, 2025 No Comments

Long-Term Results with Adjuvant Ozone Therapy in the Management of Chronic Pelvic Pain Secondary to Cancer Treatment

This 2021 study evaluated the long-term efficacy of adjuvant ozone therapy (O₃T) in managing chronic pelvic pain in cancer survivors. Six patients with refractory pelvic pain, unresponsive to standard treatments, received O₃T via rectal insufflation. Pain levels, assessed using the Visual Analog Scale (VAS), showed significant reductions: continuous pelvic pain

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June 26, 2025 No Comments

Intravenous ozonized saline therapy as prophylaxis for healthcare workers (HCWs) in a dedicated COVID-19 hospital in India – A retrospective study

This retrospective controlled cohort study evaluated the use of intravenous ozonized saline as a prophylactic treatment for COVID-19 in healthcare workers (HCWs). A total of 235 HCWs were divided into two groups: 64 received ozone therapy in addition to standard prophylaxis, while 171 received only standard care. The results showed

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June 26, 2025 No Comments