This 2024 comprehensive review titled "Ozone therapy in musculoskeletal medicine: a comprehensive review" (European Journal of Medical Research, DOI: [10.1186/s40001-024-01976-4*) evaluated the use of ozone therapy in treating musculoskeletal conditions such as osteoarthritis, lumbar disc herniation, tendinopathies, and myofascial pain syndromes. The review described ozone’s mechanisms—enhancing oxygen metabolism, modulating oxidative