This cohort study, published in Obstetrics & Gynecology (2023), evaluated the safety of vaginal estrogen therapy (VET) for treating genitourinary syndrome of menopause (GSM) in women with a history of breast cancer. Analyzing data from 42,113 women diagnosed with GSM after breast cancer treatment, with 5.0% receiving VET, the study
This meta-analysis examined the effectiveness of testosterone therapy in postmenopausal women with hypoactive sexual desire disorder (HSDD). The therapy, delivered through transdermal patches or topical gels, significantly improved sexual desire and activity, with patients experiencing enhanced sexual satisfaction. It was well-tolerated, with side effects such as weight gain, acne, and
This study examined the sedative and hypnotic effects of orally administered micronized progesterone in eight postmenopausal women. A 400 mg dose induced a hypnotic state lasting approximately two hours in one participant, while serum levels of progesterone and its metabolites peaked between 2 to 6 hours post-administration. The study identified
This review evaluates the effectiveness of testosterone therapy in postmenopausal women, particularly for treating sexual dysfunction. It highlights that low-dose testosterone, when combined with estrogen, significantly improves sexual desire, arousal, frequency, and satisfaction, with no serious adverse effects reported in studies lasting up to two years. The review suggests testosterone
This observational study examined the relationship between serum estrogen levels after hormone replacement therapy (HRT) and body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. It found that daily HRT administration led to a significant positive correlation between serum estradiol levels and BMI (P < 0.05 and P <
A randomized controlled trial published in the New England Journal of Medicine examined the effects of testosterone therapy on fracture risk in men with hypogonadism. The study included 5,204 men aged 45 to 80 with hypogonadism and cardiovascular risk factors, who were randomized to receive either testosterone gel or placebo
This case-control study examined the association between serum testosterone levels and prostate cancer risk, highlighting potential implications for testosterone therapy. Analyzing 794 male participants from the Baltimore Longitudinal Study of Aging, researchers found that men with higher free testosterone levels had a significantly increased risk of prostate cancer (RR 2.59,
A randomized controlled trial published in the Journal of Clinical Endocrinology & Metabolism examined the effects of testosterone therapy on sexual function in older men with low testosterone levels. The study included 470 men aged 65 and older with testosterone levels below 275 ng/dL and symptoms of sexual dysfunction, physical
This article examines the impact of menopause on women’s sexuality, highlighting challenges in assessing hormone levels due to ethnic variability and measurement limitations. It discusses differences in prevalence rates of female sexual dysfunction between cross-sectional and longitudinal studies and critiques traditional models of sexual response. The study also notes the
A meta-analysis published in The Journal of Sexual Medicine reviewed data from two Phase III trials (INTIMATE SM 1 and 2) assessing the efficacy and safety of transdermal testosterone therapy in surgically postmenopausal women with hypoactive sexual desire disorder (HSDD) undergoing estrogen therapy. Women receiving testosterone experienced significant improvements in
