Well Referenced

Tag: hormone replacement therapy

Testosterone use in men and its effects on bone health. A systematic review and meta-analysis of randomized placebo-controlled trials

A meta-analysis published in The Journal of Clinical Endocrinology & Metabolism evaluated the effects of testosterone therapy on bone mineral density (BMD) in men by analyzing eight randomized placebo-controlled trials with 365 participants. The study found that intramuscular testosterone administration led to an 8% increase in lumbar spine BMD (95%

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June 26, 2025 No Comments

Study of adverse outcomes in women using testosterone therapy

This cohort study analyzed data from 2,103 women using testosterone therapy (via implants, tablets, or injections) and 6,309 matched controls to assess adverse health outcomes. The findings indicate that testosterone therapy does not significantly increase the risk of cardiovascular disease, breast cancer, diabetes, or deep vein thrombosis, but it is

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June 26, 2025 No Comments

Testosterone use in men with sexual dysfunction: a systematic review and meta-analysis of randomized placebo-controlled trials

A meta-analysis published in Mayo Clinic Proceedings reviewed randomized placebo-controlled trials to evaluate the effects of testosterone therapy on sexual dysfunction in men. The study found that testosterone therapy significantly improved sexual desire and erectile function compared to placebo, though the effect sizes were modest and varied across studies. No

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June 26, 2025 No Comments

Testosterone: its role in development of prostate cancer and potential risk from use as hormone replacement therapy

A systematic review published in Drugs & Aging examined the relationship between testosterone levels and prostate cancer development, as well as the potential risks associated with testosterone replacement therapy (TRT) in aging men. The review found that men with low testosterone levels often develop more malignant and treatment-resistant prostate cancers.

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June 26, 2025 No Comments

Low-dose hormone replacement therapy: effects on bone

This study examines the effects of low-dose hormone replacement therapy (HRT) on bone health in postmenopausal women. It found that low-dose HRT effectively alleviates climacteric symptoms while minimizing side effects like unscheduled bleeding. Additionally, when combined with calcium supplementation, it helps prevent bone loss, reducing the risk of osteoporosis in

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June 26, 2025 No Comments

Management of postmenopausal symptoms in breast cancer survivors

This review addresses the management of menopausal symptoms in breast cancer survivors, focusing on the challenges of treating symptoms such as hot flashes, vaginal dryness, and osteoporosis without the use of traditional hormone replacement therapy (HRT), which is contraindicated due to its association with increased breast cancer recurrence. The article

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June 26, 2025 No Comments

Menopausal estrogen and estrogen-progestin replacement therapy and breast cancer risk

This cohort study evaluated the breast cancer risks associated with menopausal hormone replacement therapy (HRT) in postmenopausal women, comparing estrogen-only therapy to estrogen-progestin therapy. The study found that both estrogen-only and estrogen-progestin therapies increased breast cancer risk, with estrogen-progestin therapy showing a higher risk, particularly in women with lower BMI.

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June 26, 2025 No Comments