This cohort study analyzed data from 49,237 women aged 40 to 79 diagnosed with breast cancer in Scotland (2010-2017) and Wales (2000-2016), with follow-up until 2020. It found that 5% of these patients used vaginal estrogen therapy (VET) post-diagnosis. After adjusting for confounders, the study found no evidence of increased
A review published in Gynecological Endocrinology analyzed the Women’s Health Initiative (WHI) findings on hormone replacement therapy (HRT) in postmenopausal women, focusing on the effects of conjugated equine estrogens (CEE) alone versus CEE combined with medroxyprogesterone acetate (MPA). The study highlighted that the high prevalence of metabolic syndrome among participants
A pilot study investigated the effects of hormone replacement therapy (HRT) on sleep-disordered breathing (SDB) in six postmenopausal women with mild to moderate SDB. Polysomnography was conducted at baseline, after 7-12 days of estrogen therapy, and again after an additional 7-13 days of combined estrogen and progesterone therapy. Estrogen alone
This study presents a hypothesis on the potential benefits of early, low-dose hormone replacement therapy (HRT) in healthy perimenopausal women, particularly in improving metabolic syndrome components and reducing cardiovascular risk. However, the article does not provide empirical data to support these claims and is based purely on theoretical assumptions. It
This observational study examined the effects of hormone replacement therapy (HRT) on cognitive performance in postmenopausal women, analyzing data from the Danish MONICA study. It found that current users of HRT experienced less decline in concentration and visuomotor function compared to non-users. Women who started HRT during the study demonstrated
This review examines the role of androgens and estrogens in aging, focusing on their impact on muscle mass, bone density, and overall physical function. In men, declining testosterone levels are linked to reduced muscle mass, bone density, and strength, while in women, estradiol deficiency primarily affects bone health, with less
This study surveyed 469 breast cancer survivors to assess the severity of menopausal symptoms and their willingness to consider hormone replacement therapy (HRT). Over 76% reported experiencing hot flushes or night sweats, with 53% rating them as severe to extreme, significantly impacting their quality of life. Among those who had
This article examines the impact of menopause on women’s sexuality, highlighting challenges in assessing hormone levels due to ethnic variability and measurement limitations. It discusses differences in prevalence rates of female sexual dysfunction between cross-sectional and longitudinal studies and critiques traditional models of sexual response. The study also notes the
A meta-analysis published in The Journal of Sexual Medicine reviewed data from two Phase III trials (INTIMATE SM 1 and 2) assessing the efficacy and safety of transdermal testosterone therapy in surgically postmenopausal women with hypoactive sexual desire disorder (HSDD) undergoing estrogen therapy. Women receiving testosterone experienced significant improvements in
This study examined the effects of short-term oral micronized progesterone on the vascular benefits of transdermal estradiol in 17 premenopausal women. Participants underwent hormone suppression with a gonadotropin-releasing hormone antagonist for 10-12 days, followed by supplementation with either 200 mg oral micronized progesterone or 0.1 mg transdermal estradiol. The results
