Well Referenced

Tag: hormone replacement therapy

Two to three years of hormone replacement treatment in healthy women have long-term preventive effects on bone mass and osteoporotic fractures: the PERF study

This study investigated the long-term benefits of short-term hormone replacement therapy (HRT) on bone health in postmenopausal women. A total of 347 healthy postmenopausal women participated in placebo-controlled trials, receiving either HRT or placebo for 2-3 years. Follow-up assessments conducted 5, 11, or 15 years after discontinuation showed that women

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June 26, 2025 No Comments

Use of compounded bioidentical hormone therapy in menopausal women: an opinion statement of the Women’s Health Practice and Research Network of the American College of Clinical Pharmacy

This article examines the use of compounded bioidentical hormone therapy (cBHT) for menopausal symptom management, raising concerns about its safety and efficacy compared to manufactured hormone therapy. The study highlights the lack of strong clinical data supporting the claimed advantages of cBHT and addresses misconceptions regarding the natural versus synthetic

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June 26, 2025 No Comments

The controversy of hormone-replacement therapy in breast cancer survivors

A review published in Oncology Nursing Forum examined the controversy surrounding hormone replacement therapy (HRT) in breast cancer survivors, focusing on its risks, benefits, and long-term health outcomes. While HRT has been associated with improved quality of life, reduced risks of cardiovascular disease, and osteoporosis prevention in postmenopausal women, its

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June 26, 2025 No Comments

The current outlook for testosterone in the management of hypoactive sexual desire disorder in postmenopausal women

A review published in The Journal of Sexual Medicine examined the role of testosterone therapy in managing hypoactive sexual desire disorder (HSDD) in postmenopausal women. The study found that testosterone treatment significantly improves sexual desire and satisfaction in this population. However, potential side effects such as hirsutism and acne were

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June 26, 2025 No Comments

Vaginal Estrogen Therapy Use and Survival in Females With Breast Cancer

This cohort study analyzed data from 49,237 women aged 40 to 79 diagnosed with breast cancer in Scotland (2010-2017) and Wales (2000-2016), with follow-up until 2020. It found that 5% of these patients used vaginal estrogen therapy (VET) post-diagnosis. After adjusting for confounders, the study found no evidence of increased

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June 26, 2025 No Comments

The effect of medroxyprogesterone acetate on estrogen-dependent risks and benefits–an attempt to interpret the Women’s Health Initiative results

A review published in Gynecological Endocrinology analyzed the Women’s Health Initiative (WHI) findings on hormone replacement therapy (HRT) in postmenopausal women, focusing on the effects of conjugated equine estrogens (CEE) alone versus CEE combined with medroxyprogesterone acetate (MPA). The study highlighted that the high prevalence of metabolic syndrome among participants

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June 26, 2025 No Comments

The effects of hormone replacement therapy on sleep-disordered breathing in postmenopausal women: a pilot study

A pilot study investigated the effects of hormone replacement therapy (HRT) on sleep-disordered breathing (SDB) in six postmenopausal women with mild to moderate SDB. Polysomnography was conducted at baseline, after 7-12 days of estrogen therapy, and again after an additional 7-13 days of combined estrogen and progesterone therapy. Estrogen alone

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June 26, 2025 No Comments

The impact of hormone replacement therapy on metabolic syndrome components in perimenopausal women

This study presents a hypothesis on the potential benefits of early, low-dose hormone replacement therapy (HRT) in healthy perimenopausal women, particularly in improving metabolic syndrome components and reducing cardiovascular risk. However, the article does not provide empirical data to support these claims and is based purely on theoretical assumptions. It

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June 26, 2025 No Comments

The influence of hormone replacement therapy on the aging-related change in cognitive performance. Analysis based on a Danish cohort study

This observational study examined the effects of hormone replacement therapy (HRT) on cognitive performance in postmenopausal women, analyzing data from the Danish MONICA study. It found that current users of HRT experienced less decline in concentration and visuomotor function compared to non-users. Women who started HRT during the study demonstrated

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June 26, 2025 No Comments