Sedative and hypnotic effects of oral administration of micronized progesterone may be mediated through its metabolites

This study examined the sedative and hypnotic effects of orally administered micronized progesterone in eight postmenopausal women. A 400 mg dose induced a hypnotic state lasting approximately two hours in one participant, while serum levels of progesterone and its metabolites peaked between 2 to 6 hours post-administration. The study identified