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Tag: α-lipoic acid

Effects of oral α-lipoic acid administration on body weight in overweight or obese subjects: a crossover randomized, double-blind, placebo-controlled trial

This 2017 randomized, double-blind, placebo-controlled crossover trial evaluated the effects of α-lipoic acid (ALA) supplementation on body weight in overweight or obese individuals. A total of 103 Chinese Han participants with a BMI ≥25 kg/m² were randomized to receive either 1200 mg/day of ALA or placebo for 8 weeks, followed

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June 26, 2025 No Comments

The Impact of Lipoic Acid on Endothelial Function and Proteinuria in Quinapril-Treated Diabetic Patients with Stage I Hypertension: Results from the QUALITY Study

This 2012 randomized, double-blind, crossover study investigated the effects of α-lipoic acid (ALA) on endothelial function and proteinuria in 40 diabetic patients with stage I hypertension receiving quinapril 40 mg/day. Participants were treated for 8 weeks with either quinapril alone or quinapril plus ALA 600 mg/day. Results showed that the

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June 26, 2025 No Comments

A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead

This review analyzes the coordination behavior and therapeutic potential of thiol-based chelators—DMSA, DMPS, BAL, and α-lipoic acid—against toxic metals mercury (Hg), cadmium (Cd), and lead (Pb). It outlines how these metals interact preferentially with sulfur-containing ligands due to their classification as soft or borderline acids. DMSA is noted for its

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June 26, 2025 No Comments

α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer’s Disease

This experimental study evaluates α-lipoic acid (LA) as a modulator of copper homeostasis in Alzheimer’s disease (AD). Through in vitro and in vivo models—including SH-SY5Y neuronal cells and Drosophila melanogaster expressing human Aβ—LA was found to promote intracellular copper uptake, potentially reversing the copper dyshomeostasis observed in AD. Supplementation with

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June 26, 2025 No Comments

Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity

This 2011 study evaluated α-lipoic acid (ALA) as a neuroprotective agent in a rat model of Parkinson’s disease (PD) induced by rotenone. Rotenone exposure led to decreased striatal complex I activity, reduced glutathione levels, increased nitrite concentrations, elevated caspase-3 activity, and ultrastructural neuronal damage, indicative of mitochondrial dysfunction and oxidative

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June 26, 2025 No Comments

α-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative condition

This 2016 in vitro study investigated the neuroprotective effects of α-lipoic acid (ALA) on dopaminergic neurons exposed to MPP+, a neurotoxin used to model Parkinson’s disease. The researchers found that ALA treatment significantly reduced neuronal apoptosis and increased the expression of proliferating cell nuclear antigen (PCNA), a key protein involved

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June 26, 2025 No Comments

α-Lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells

This 2020 study investigated the effects of α-lipoic acid (ALA) on ionizing radiation (IR)-induced epithelial-mesenchymal transition (EMT) and radiosensitivity in breast cancer cells. The findings revealed that ALA treatment inhibited IR-induced EMT by downregulating mesenchymal markers (e.g., vimentin, N-cadherin) and upregulating epithelial markers (e.g., E-cadherin). Additionally, ALA enhanced the radiosensitivity

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June 26, 2025 No Comments

The contributions of antioxidant activity of lipoic acid in reducing neurodegenerative progression of Parkinson’s disease: a review

This 2011 review explores the neuroprotective potential of α-lipoic acid (ALA) in Parkinson’s disease (PD). It discusses how ALA, a universal antioxidant, mitigates oxidative stress—a key factor in PD pathogenesis—by scavenging reactive oxygen species and enhancing antioxidant defenses. The review highlights ALA’s amphipathic nature, allowing it to act in both

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June 26, 2025 No Comments

The Disulfide Compound α-Lipoic Acid and Its Derivatives: A Novel Class of Anticancer Agents Targeting Mitochondria

This 2015 review explores α-lipoic acid (ALA), a mitochondrial cofactor with potent antioxidant properties, and its derivatives as emerging anticancer agents. ALA induces apoptosis in cancer cells by targeting mitochondrial pathways, while sparing normal cells. It impairs oncogenic signaling and exhibits anti-metastatic effects. Novel derivatives like CPI-613 disrupt mitochondrial energy

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June 26, 2025 No Comments

The Long-Term Survival of a Patient With Stage IV Renal Cell Carcinoma Following an Integrative Treatment Approach Including the Intravenous α-Lipoic Acid/Low-Dose Naltrexone Protocol

This 2018 case report presents the clinical course of a patient with Stage IV renal cell carcinoma who achieved long-term survival following an integrative treatment protocol initiated after failure of conventional therapies. The regimen included intravenous α-lipoic acid, vitamin C, low-dose naltrexone (LDN), hydroxycitrate, and comprehensive lifestyle changes. The treatment

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June 26, 2025 No Comments