This 2011 review explores the neuroprotective potential of α-lipoic acid (ALA) in Parkinson’s disease (PD). It discusses how ALA, a universal antioxidant, mitigates oxidative stress—a key factor in PD pathogenesis—by scavenging reactive oxygen species and enhancing antioxidant defenses. The review highlights ALA's amphipathic nature, allowing it to act in both