This animal study examined the effects of α-lipoic acid (ALA) supplementation on oxidative stress, inflammation, and glucose metabolism in insulin-resistant rats. Male Wistar rats were divided into four groups (control diet, high-fat diet, control diet + ALA, and high-fat diet + ALA) and given 30 mg/kg body weight of ALA
The study “Alpha Lipoic Acid Attenuates ER Stress and Improves Glucose Uptake Through DNAJB3 Cochaperone” (Scientific Reports, 2020, PMID: 33235302) investigated the effects of α-lipoic acid (ALA) on endoplasmic reticulum (ER) stress and glucose uptake in C2C12 muscle cells and HepG2 liver cells. ALA treatment significantly increased DNAJB3 mRNA and
The study titled “Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects” examined the impact of α-lipoic acid (ALA) on insulin sensitivity and lipid profiles in 22 obese individuals with impaired glucose tolerance (IGT). Over a 2-week period, 13 participants received 600 mg of ALA intravenously once
The systematic review and dose-response meta-analysis titled “An updated systematic review and dose-response meta-analysis of the effects of α-lipoic acid supplementation on glycemic markers in adults” investigated the impact of α-lipoic acid (ALA) supplementation on glycemic markers, including glucose, hemoglobin A1c (HbA1c), insulin, and insulin resistance indices in adults. The
This systematic review and meta-analysis examined the effects of intravenous α-lipoic acid (ALA) at doses of 300 to 600 mg per day on diabetic peripheral neuropathy (DPN). Analyzing 15 randomized controlled trials, the study found that ALA significantly improved nerve conduction velocities in both motor and sensory nerves, with a
This in vitro study, published in Archives of Toxicology (2015, PMID: 25526924), examined the effects of alpha-lipoic acid (LA) on colorectal cancer (CRC) cells, demonstrating that LA induces cell death regardless of p53 status and enhances the cytotoxic effects of 5-fluorouracil (5-FU). Conducted on various CRC cell lines, the study
The study titled “Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies” (Antioxidants (Basel), 2020, PMID: 33086555) assessed the safety of α-lipoic acid (ALA) supplementation by analyzing data from 71 randomized placebo-controlled trials involving 4,749 participants (2,558 receiving ALA and 2,294 on placebo).
The study titled “α-lipoic acid in patients with autosomal dominant polycystic kidney disease” (Nutrition, 2020, PMID: 31790890) investigated the effects of α-lipoic acid (ALA) supplementation on systemic inflammation, endothelial dysfunction, and atherosclerosis in patients with autosomal dominant polycystic kidney disease (ADPKD). In a six-month intervention, 33 patients received 1.6 g
The study titled “α-Lipoic acid inhibits human lung cancer cell proliferation through Grb2-mediated EGFR downregulation” (Biochem Biophys Res Commun, 2017, PMID: 28993193) is an in vitro/animal study investigating the effects of α-lipoic acid (α-LA) on non-small cell lung cancer (NSCLC) cells. The findings indicate that α-LA suppresses NSCLC cell proliferation
The study titled “α-Lipoic acid sensitizes lung cancer cells to chemotherapeutic agents and anoikis via integrin β1/β3 downregulation” (PMID: 27431988) explored the effects of α-lipoic acid (LA) on lung cancer cells. This in vitro study found that LA increased reactive oxygen species levels, leading to the downregulation of integrin β1
