α-lipoic acid exerts neuroprotective effects on neuronal cells by upregulating the expression of PCNA via the P53 pathway in neurodegenerative condition

This 2016 in vitro study investigated the neuroprotective effects of α-lipoic acid (ALA) on dopaminergic neurons exposed to MPP+, a neurotoxin used to model Parkinson’s disease. The researchers found that ALA treatment significantly reduced neuronal apoptosis and increased the expression of proliferating cell nuclear antigen (PCNA), a key protein involved