α-Lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells

This 2020 study investigated the effects of α-lipoic acid (ALA) on ionizing radiation (IR)-induced epithelial-mesenchymal transition (EMT) and radiosensitivity in breast cancer cells. The findings revealed that ALA treatment inhibited IR-induced EMT by downregulating mesenchymal markers (e.g., vimentin, N-cadherin) and upregulating epithelial markers (e.g., E-cadherin). Additionally, ALA enhanced the radiosensitivity