Nutritional support for disease prevention and cellular health.
This observational study examined the relationship between iron status markers and symptoms in 780 non-anemic, menstruating women in France, focusing on fatigue, cognitive function, and quality of life. Among the 554 women included in the final analysis, lower ferritin levels were significantly associated with symptoms like fatigue, reduced physical performance,
This review article explores how genetic variations affect choline metabolism and dietary requirements. It highlights that men and postmenopausal women are more likely to experience liver or muscle dysfunction when deprived of dietary choline, while premenopausal women may resist choline deficiency due to estrogen-induced expression of the PEMT gene, which
This 2022 review article explores the widespread prevalence, symptoms, and treatment options for iron deficiency (ID) in women, with or without anemia. It highlights that ID is commonly caused by factors like poor diet, menstruation, pregnancy, and inflammation, and presents with symptoms such as fatigue, cognitive impairment, and poor immune
This symposium summary discusses the roles of S-adenosylmethionine (SAMe), folate, and betaine in treating alcoholic liver disease (ALD), focusing on their biochemical functions and therapeutic potential. These compounds act as methyl donors essential for hepatic transmethylation reactions, impacting homocysteine metabolism and influencing gene expression related to liver health. Deficiencies in
This review article on Iron Deficiency Anemia (IDA) outlines its widespread prevalence, particularly due to menstrual blood loss and gastrointestinal bleeding. It emphasizes that iron deficiency impacts more than hemoglobin levels, leading to symptoms like fatigue, hair loss, and restless legs syndrome. Serum ferritin is identified as the most accurate
This study examined coenzyme Q10 (CoQ10) deficiency in Parkinson’s disease (PD) patients compared to age- and gender-matched controls, revealing a significantly higher prevalence of CoQ10 deficiency in PD patients (32-36%) versus controls (8-9%), with odds ratios ranging from 4.7 to 5.4 (p=0.0012-0.006). CoQ10 plays a crucial role in mitochondrial function
This randomized controlled trial examined the effects of Coenzyme Q10 (CoQ10) supplementation on inflammatory and endothelial dysfunction markers in overweight and obese women with Polycystic Ovary Syndrome (PCOS). Over 8 weeks, CoQ10 significantly reduced levels of TNF-α, hs-CRP, IL-6, VCAM-1, and E-selectin, indicating improved inflammatory status and vascular function, although
This systematic review analyzed 14 studies involving 1,067 predominantly older adult males and evaluated the effectiveness of Coenzyme Q10 (CoQ10) as adjunctive therapy in patients with cardiovascular disease (CVD) and hypertension. Findings indicated that CoQ10 supplementation improved functional capacity in heart failure patients, increased serum CoQ10 levels, reduced major cardiovascular
This review article introduces the mitochondrial-stem cell connection (MSCC) theory, suggesting that cancer originates from chronic oxidative phosphorylation (OxPhos) dysfunction in stem cells, leading to the formation of cancer stem cells (CSCs). The proposed hybrid orthomolecular protocol integrates orthomolecules (e.g., vitamins C and D, zinc), repurposed drugs (e.g., ivermectin, benzimidazoles),
This article reviews the effectiveness of chelation therapy in treating atherosclerosis, particularly in diabetic patients who have experienced a myocardial infarction (MI). Based on findings from the Trial to Assess Chelation Therapy (TACT), the therapy was shown to reduce cardiovascular events by 41% in post-MI patients with diabetes, leading to
