This randomized controlled trial examined the effects of Coenzyme Q10 (CoQ10) supplementation on inflammatory and endothelial dysfunction markers in overweight and obese women with Polycystic Ovary Syndrome (PCOS). Over 8 weeks, CoQ10 significantly reduced levels of TNF-α, hs-CRP, IL-6, VCAM-1, and E-selectin, indicating improved inflammatory status and vascular function, although