Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility

This meta-analysis evaluated the effects of L-carnitine and L-acetylcarnitine supplementation in men with idiopathic infertility, finding that carnitine supplementation significantly improved sperm motility and morphology but had no significant effect on sperm concentration or pregnancy rates. L-carnitine and L-acetylcarnitine function as antioxidants, reducing oxidative stress, a key contributor to male

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June 26, 2025 No Comments

Thyroid, Diet, and Alternative Approaches

The article “Thyroid, Diet, and Alternative Approaches” explores the impact of various dietary supplements, complementary medicines, and dietary modifications on thyroid disorder management. It highlights that iodine supplementation via universal salt iodization has effectively prevented severe thyroid diseases, but excessive iodine intake can contribute to thyroid dysfunction. Selenium and zinc

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June 26, 2025 No Comments

Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP+ induced toxicity via ameliorating oxidative stress and mitochondrial dysfunction

Methylene blue (MB) demonstrates neuroprotective potential against MPP+-induced neurotoxicity, a model for Parkinson’s disease, by reducing oxidative stress and mitochondrial dysfunction. The study, conducted in vitro and in animal models, highlights MB’s ability to restore mitochondrial complex I activity, increase ATP levels, and activate the Nrf2 pathway via AKT signaling,

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June 26, 2025 No Comments

Cancer risk and oxidative DNA damage in man

This review explores the relationship between oxidative DNA damage and cancer risk in humans, highlighting how reactive oxygen species (ROS) contribute to DNA lesions that may lead to mutations and carcinogenesis. It discusses the body’s defense mechanisms against oxidative stress and the potential role of antioxidants in cancer prevention. The

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June 26, 2025 No Comments

The effects of vitamin B1 on ameliorating the premenstrual syndrome symptoms

A double-blind, placebo-controlled clinical trial examined the effects of vitamin B1 on premenstrual syndrome (PMS) symptoms among 80 students at Jahrom University of Medical Sciences. Participants were randomly assigned to receive either vitamin B1 or a placebo. The study found that vitamin B1 significantly reduced both mental (35.08%) and physical

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June 26, 2025 No Comments

Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects

The study titled “Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects” examined the impact of α-lipoic acid (ALA) on insulin sensitivity and lipid profiles in 22 obese individuals with impaired glucose tolerance (IGT). Over a 2-week period, 13 participants received 600 mg of ALA intravenously once

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June 26, 2025 No Comments

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

The meta-analysis titled “The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials” evaluated the impact of alpha-lipoic acid (ALA) supplementation on glucose homeostasis and lipid profiles in individuals with metabolic diseases. The analysis

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June 26, 2025 No Comments

Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial

This placebo-controlled pilot study investigated the effects of alpha-lipoic acid (ALA) on insulin sensitivity in patients with type-2 diabetes mellitus. Seventy-four participants were randomized to receive either a placebo or ALA at doses of 600 mg once daily, 1200 mg twice daily, or 1800 mg thrice daily for 4 weeks.

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June 26, 2025 No Comments