Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

Oxidative stress and mitochondrial dysfunction across broad-ranging pathologies: toward mitochondria-targeted clinical strategies

This systematic review examines the role of oxidative stress and mitochondrial dysfunction in a wide range of chronic diseases, including neurodegenerative disorders, cardiovascular disease, metabolic syndrome, cancer, and age-related conditions. The review underscores the damaging cycle of reactive oxygen species (ROS) and mitochondrial impairment, which drives cellular decline. It highlights

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June 26, 2025 No Comments

Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia

This animal study investigated the effects of phosphatidylcholine (PC) supplementation on memory performance and brain acetylcholine levels in dementia-model and normal mice. Dementia-model mice exhibited significantly poorer memory and lower brain acetylcholine concentrations than normal controls (p < 0.05). After 45 days of daily PC administration (100 mg), dementia-model mice

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June 26, 2025 No Comments

Redefining Iron Deficiency in Patients With Chronic Heart Failure

This review article redefines iron deficiency in patients with chronic heart failure (CHF), arguing that current diagnostic criteria based on serum ferritin and transferrin saturation may miss cases of functional iron deficiency at the tissue level. It emphasizes the importance of intracellular iron for mitochondrial function and energy production in

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June 26, 2025 No Comments

Choline intake in a large cohort of patients with nonalcoholic fatty liver disease

This observational study examined the relationship between dietary choline intake and liver fibrosis severity in patients with nonalcoholic fatty liver disease (NAFLD). The findings revealed that postmenopausal women with lower choline intake had significantly worse fibrosis (p=0.002), even after adjusting for factors such as age, obesity, triglycerides, diabetes, alcohol use,

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June 26, 2025 No Comments

Maternal choline supplementation during the third trimester of pregnancy improves infant information processing speed: a randomized, double-blind, controlled feeding study

This randomized controlled trial examined the effects of maternal choline supplementation during the third trimester on infant cognitive function. Pregnant women consumed either 480 mg/day or 930 mg/day of choline until delivery, with infant cognitive assessments conducted at 4, 7, 10, and 13 months of age. Infants of mothers who

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June 26, 2025 No Comments

Nutritional genomics: defining the dietary requirement and effects of choline

This review article explores how genetic variations affect choline metabolism and dietary requirements. It highlights that men and postmenopausal women are more likely to experience liver or muscle dysfunction when deprived of dietary choline, while premenopausal women may resist choline deficiency due to estrogen-induced expression of the PEMT gene, which

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June 26, 2025 No Comments