This review article introduces the mitochondrial-stem cell connection (MSCC) theory, suggesting that cancer originates from chronic oxidative phosphorylation (OxPhos) dysfunction in stem cells, leading to the formation of cancer stem cells (CSCs). The proposed hybrid orthomolecular protocol integrates orthomolecules (e.g., vitamins C and D, zinc), repurposed drugs (e.g., ivermectin, benzimidazoles),
