Well Referenced

Category: Vitamins, Supplements & Antioxidants

Nutritional support for disease prevention and cellular health.

A Randomized Controlled Trial to Prevent Post-Operative Atrial Fibrillation by Antioxidant Reinforcement

This 2013 randomized controlled trial by Rodrigo et al., published in Frontiers in Cardiovascular Medicine, investigated the efficacy of antioxidant reinforcement in preventing postoperative atrial fibrillation (POAF) in patients undergoing cardiac surgery. The study enrolled 120 patients scheduled for coronary artery bypass grafting (CABG), randomly assigning them to receive either

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June 26, 2025 No Comments

Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne

This 2012 randomized, placebo-controlled clinical trial published in Journal of Clinical & Experimental Dermatology Research evaluated the efficacy of oral antioxidants—silymarin, N-acetylcysteine (NAC), and selenium—in treating papulopustular acne. Fifty-six patients with acne vulgaris were assigned to receive one of the antioxidants or a placebo over an eight-week period. The study

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June 26, 2025 No Comments

Vitamin supplementation of HIV-infected women improves postnatal child growth

This randomized, double-blind, placebo-controlled trial conducted in Dar es Salaam, Tanzania, assessed the impact of maternal vitamin supplementation on the growth of children born to HIV-infected women. A total of 1,078 HIV-positive pregnant women were enrolled and randomized to receive daily supplements of multivitamins (vitamins B, C, and E), vitamin

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June 26, 2025 No Comments

Selenium and Coronary Heart Disease: A Meta-Analysis

This 2006 meta-analysis by Flores-Mateo et al., published in The American Journal of Clinical Nutrition, systematically evaluated the association between selenium levels and the risk of coronary heart disease (CHD). Analyzing data from 25 observational studies encompassing over 14,000 participants, the study found that higher selenium concentrations were associated with

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June 26, 2025 No Comments

The Importance of Selenium to Human Health

This 2000 review by M.P. Rayman, published in The Lancet, provides a comprehensive overview of selenium’s critical role in human health. Selenium, an essential trace mineral, is integral to the function of selenoproteins, which have structural and enzymatic roles, notably as antioxidants and in the activation of thyroid hormones. The

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June 26, 2025 No Comments

The Role of Selenium in Pathologies: An Updated Review

This comprehensive 2022 review in Antioxidants explores selenium’s multifaceted role in human health, emphasizing its incorporation into at least 25 selenoproteins that regulate oxidative stress, hormone synthesis, and immune function. The authors detail selenium’s involvement in various pathologies, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, fertility issues, and infections like

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June 26, 2025 No Comments

Long-term oral N-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD

In this 2005 randomized, double-blind, placebo-controlled trial, De Benedetto et al. investigated the effects of long-term oral N-acetylcysteine (NAC) on oxidative stress in patients with stable chronic obstructive pulmonary disease (COPD). Fifty-five patients (mean age 65.9 years; 48 males), all non-smokers or ex-smokers for at least five years, were randomized

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June 26, 2025 No Comments

N-Acetylcysteine (NAC): Impacts on Human Health

In this 2021 review, Tenório et al. examine the multifaceted roles of N-acetylcysteine (NAC) in human health. NAC, recognized by the FDA and WHO, is primarily used to treat acetaminophen overdose and as a mucolytic agent in respiratory diseases. Its therapeutic potential extends to conditions characterized by oxidative stress and

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June 26, 2025 No Comments

N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial

In this 2012 randomized, double-blind, placebo-controlled trial, Afshar et al. evaluated the efficacy of N-acetylcysteine (NAC) as an adjunctive treatment for patients with treatment-refractory obsessive-compulsive disorder (OCD). Forty-eight participants (mean age 30.9 years; 75% female) who had not responded to serotonin reuptake inhibitors (SRIs) were randomized to receive either NAC

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June 26, 2025 No Comments