Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials

This 2021 systematic review and meta-analysis evaluated the association between testosterone replacement therapy (TRT) and venous thromboembolism (VTE) risk by analyzing 13 randomized controlled trials encompassing 5,050 men. The pooled data indicated no significant increase in VTE risk among men receiving TRT compared to placebo (RR: 1.03; 95% CI: 0.49–2.14;