Well Referenced

Tag: TRT

Testosterone replacement therapy and the risk of venous thromboembolism: A systematic review and meta-analysis of randomized controlled trials

This 2021 systematic review and meta-analysis evaluated the association between testosterone replacement therapy (TRT) and venous thromboembolism (VTE) risk by analyzing 13 randomized controlled trials encompassing 5,050 men. The pooled data indicated no significant increase in VTE risk among men receiving TRT compared to placebo (RR: 1.03; 95% CI: 0.49–2.14;

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June 26, 2025 No Comments

Correlation between simultaneous PSA and serum testosterone concentrations among eugonadal, untreated hypogonadal and hypogonadal men receiving testosterone replacement therapy

This observational study analyzed the relationship between serum testosterone levels and prostate-specific antigen (PSA) in three groups: eugonadal men, untreated hypogonadal men, and hypogonadal men receiving testosterone replacement therapy (TRT). The study found no significant correlation between PSA levels and testosterone concentrations across all groups. Despite significant increases in testosterone

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June 26, 2025 No Comments

Testosterone and Sexual Function

This review explores the impact of testosterone replacement therapy (TRT) on sexual function, particularly in men with hypogonadism, mixed conditions, or even those with normal testosterone levels. It highlights that TRT significantly improves sexual function outcomes such as libido, erectile function, and ejaculatory function, though the degree of improvement varies

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June 26, 2025 No Comments

Hypogonadism, ADAM, and hormone replacement

This review article discusses male hypogonadism, or testosterone deficiency syndrome (TDS), a condition characterized by inadequate testosterone production, leading to symptoms such as fatigue, erectile dysfunction, cognitive changes, and altered body composition. It classifies hypogonadism into primary (e.g., genetic disorders like Klinefelter’s syndrome) and secondary causes (e.g., hypothalamic or pituitary

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June 26, 2025 No Comments