This review explores the association between androgen deficiency—specifically reductions in testosterone (T), dehydroepiandrosterone (DHEA), and its sulfate (DHEA-S)—and memory impairment in aging and Alzheimer's disease (AD). It highlights that hypoandrogenism correlates with cognitive decline, potentially due to its influence on tau protein hyperphosphorylation, a hallmark of AD pathology. While animal
