Well Referenced

Tag: memory impairment

Efficacy of CDP-choline in the Treatment of Senile Alterations in Memory

This study explored the impact of CDP-choline (citicoline) on age-related memory decline. The research indicated that aging may impair cognitive function due to decreased synthesis or increased breakdown of choline-containing phospholipids, essential for neuronal membrane integrity. Administration of CDP-choline was found to increase brain levels of phosphatidylcholine and related phospholipids,

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June 26, 2025 No Comments

Relationship between androgen deficiency and memory impairment in aging and Alzheimer’s disease

This review explores the association between androgen deficiency—specifically reductions in testosterone (T), dehydroepiandrosterone (DHEA), and its sulfate (DHEA-S)—and memory impairment in aging and Alzheimer’s disease (AD). It highlights that hypoandrogenism correlates with cognitive decline, potentially due to its influence on tau protein hyperphosphorylation, a hallmark of AD pathology. While animal

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June 26, 2025 No Comments

LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment

This 2023 in vivo animal study published in Scientific Reports (DOI: 10.1038/s41598-023-32798-9) explored how systemic inflammation induced by lipopolysaccharide (LPS) affects microglial activation, synaptic function, and cognition. Using a mouse model, researchers found that microglial activation peaked 3 days after LPS injection and was followed by GABAergic synaptic impairments and

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June 26, 2025 No Comments

Methylene blue stimulates substrate-level phosphorylation catalysed by succinyl-CoA ligase in the citric acid cycle

This study investigated the effects of methylene blue on memory impairment in a rat model of Alzheimer’s disease (AD), focusing on its impact on cytochrome c oxidase (CCO) activity and mitochondrial function. The study found that methylene blue significantly improved spatial memory and increased CCO activity, suggesting enhanced mitochondrial function,

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June 26, 2025 No Comments

Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations

This study explores the role of pregnenolone sulfate (PREG-S) in cognitive functions, particularly its effects on aging and memory impairment. The research shows that PREG-S improves cognitive performance in aging rats by increasing acetylcholine release, enhancing paradoxical sleep, and promoting neurogenesis in the hippocampus, which are crucial for memory processes.

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June 26, 2025 No Comments