This 2021 review evaluates how different formulations, dosages, and administration routes of menopausal hormone therapy (MHT) influence cardiovascular disease (CVD) risk. Oral unopposed estrogens positively affect lipoprotein levels, glycemia, and insulin sensitivity, but adding progestogens can attenuate these benefits. Micronized progesterone has the least negative impact among progestogens. Transdermal estrogens
