This 2018 review article explores melatonin's multifaceted anticancer effects across the established hallmarks of cancer. Melatonin interferes with sustained proliferative signaling by inhibiting pathways such as HIF-1α, NF-κB, and PI3K/Akt, and modulates estrogen receptor activity. It promotes genomic stability through antioxidant activity, DNA repair enhancement, and telomerase inhibition. Melatonin induces
