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Tag: cancer hallmarks

The Warburg Effect and the Hallmarks of Cancer

This conceptual review explores how the Warburg effect—characterized by cancer cells favoring aerobic glycolysis over oxidative phosphorylation—intersects with the established hallmarks of cancer. The authors argue that this metabolic reprogramming is not merely a consequence but a driver of tumorigenesis. The shift to glycolysis results in reduced ATP yield, compelling

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June 26, 2025 No Comments

Melatonin and Cancer Hallmarks

This 2018 review article explores melatonin’s multifaceted anticancer effects across the established hallmarks of cancer. Melatonin interferes with sustained proliferative signaling by inhibiting pathways such as HIF-1α, NF-κB, and PI3K/Akt, and modulates estrogen receptor activity. It promotes genomic stability through antioxidant activity, DNA repair enhancement, and telomerase inhibition. Melatonin induces

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June 26, 2025 No Comments