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Tag: HIF-1α

Melatonin and Cancer Hallmarks

This 2018 review article explores melatonin’s multifaceted anticancer effects across the established hallmarks of cancer. Melatonin interferes with sustained proliferative signaling by inhibiting pathways such as HIF-1α, NF-κB, and PI3K/Akt, and modulates estrogen receptor activity. It promotes genomic stability through antioxidant activity, DNA repair enhancement, and telomerase inhibition. Melatonin induces

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June 26, 2025 No Comments

Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study

A cohort study published in Lancet Oncology (2008) examined the role of tumor hypoxia and angiogenesis markers in predicting the outcome of radical treatments for localized prostate cancer. The study found that high expression levels of VEGF and HIF-1α were linked to shorter biochemical failure-free survival in both radiotherapy and

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June 26, 2025 No Comments