Well Referenced

Tag: angiogenesis inhibition

Repurposed Itraconazole for Use in the Treatment of Malignancies as a Promising Therapeutic Strategy

This 2022 review evaluates itraconazole, a triazole antifungal, as a repurposed anticancer agent. Itraconazole demonstrates anti-tumor activity by inhibiting angiogenesis and multiple oncogenic signaling pathways, notably the Hedgehog pathway. Preclinical studies show its efficacy in various solid and hematological malignancies. Clinical trials have reported benefits in prostate, lung, and basal

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June 26, 2025 No Comments

Repurposing Itraconazole as a Treatment for Advanced Prostate Cancer: A Noncomparative Randomized Phase II Trial in Men With Metastatic Castration-Resistant Prostate Cancer

This 2013 phase II trial evaluated the antifungal drug itraconazole as a potential therapy for chemotherapy-naïve men with metastatic castration-resistant prostate cancer (mCRPC). Forty-six patients were randomized to receive either low-dose (200 mg/day) or high-dose (600 mg/day) oral itraconazole. The primary endpoint was the 24-week prostate-specific antigen (PSA) progression-free survival

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June 26, 2025 No Comments

Melatonin and Cancer Hallmarks

This 2018 review article explores melatonin’s multifaceted anticancer effects across the established hallmarks of cancer. Melatonin interferes with sustained proliferative signaling by inhibiting pathways such as HIF-1α, NF-κB, and PI3K/Akt, and modulates estrogen receptor activity. It promotes genomic stability through antioxidant activity, DNA repair enhancement, and telomerase inhibition. Melatonin induces

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June 26, 2025 No Comments

Melatonin as a treatment for gastrointestinal cancer: a review

This 2015 review examines melatonin’s potential as a therapeutic agent against gastrointestinal (GI) cancers. It highlights the association between disrupted melatonin rhythms and increased GI cancer risk, as evidenced by epidemiological and experimental studies. Melatonin’s anticancer mechanisms include inhibition of cell proliferation, invasion, metastasis, and angiogenesis, as well as promotion

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June 26, 2025 No Comments

Melatonin for the prevention and treatment of cancer

This 2017 review explores melatonin’s potential as a preventive and therapeutic agent against various cancers, including breast, prostate, gastric, and colorectal cancers. Melatonin exhibits multiple anticancer mechanisms: it acts as a potent antioxidant, modulates MT1 and MT2 melatonin receptors, induces apoptosis, regulates pro-survival signaling pathways and tumor metabolism, inhibits angiogenesis

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June 26, 2025 No Comments