Impact of Antioxidants on the Ability of Phenolic Phytochemicals to Kill HCT116 Colon Cancer Cells

This study investigated how antioxidants affect the cytotoxicity of phenolic phytochemicals, specifically epigallocatechin gallate (EGCG) and curcumin, on HCT116 colon cancer cells. Both compounds induced DNA damage and apoptosis in these cells. However, the presence of antioxidants like ascorbate and N-acetylcysteine (NAC) inhibited EGCG-induced DNA damage and apoptosis, but did