This 1976 study by Cameron and Pauling evaluated the effect of high-dose vitamin C (10 g/day, initially IV then oral) on survival in 100 terminal cancer patients compared to 1,000 matched controls. Results showed significantly prolonged survival in the ascorbate group, with a mean survival extension of around 300 days
This 2014 study explores how pharmacological doses of ascorbate (vitamin C) impact the epigenetic landscape of human metastatic melanoma cells. Researchers found that high concentrations of ascorbate (8 mM) significantly inhibited DNA methyltransferase (DNMT) activity but had no effect on histone deacetylase (HDAC) function. Additionally, ascorbate treatment resulted in the
This study investigated how antioxidants affect the cytotoxicity of phenolic phytochemicals, specifically epigallocatechin gallate (EGCG) and curcumin, on HCT116 colon cancer cells. Both compounds induced DNA damage and apoptosis in these cells. However, the presence of antioxidants like ascorbate and N-acetylcysteine (NAC) inhibited EGCG-induced DNA damage and apoptosis, but did
This expert commentary by Barry Halliwell analyzes and contextualizes the findings from Ghanem et al., who reported that high-dose ascorbate (vitamin C) selectively induces death in breast cancer cells through redox imbalance and metabolic disruption. The mechanism involves increased oxidative stress, mitochondrial dysfunction, ATP depletion, and a shift in cellular
This study presents a convenient method for measuring blood ascorbate (vitamin C) concentrations in patients receiving high-dose intravenous ascorbate. The method offers a more efficient and accurate way to monitor vitamin C levels during treatment, aiding in the optimization of therapy. The study highlights the importance of monitoring ascorbate levels
