Well Referenced

Tag: curcumin

Dietary Factors Promoting Brown and Beige Fat Development and Thermogenesis

This 2017 review synthesizes current evidence on how specific dietary components influence brown adipose tissue (BAT) activation and the browning of white adipose tissue (WAT), processes that enhance thermogenesis and energy expenditure. The authors highlight several dietary molecules, including phytochemicals like capsaicin, resveratrol, curcumin, green tea catechins, and berberine; dietary

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June 26, 2025 No Comments

A Combination Cocktail Improves Spatial Attention in a Canine Model of Human Aging and Alzheimer’s Disease

This experimental study assessed the cognitive effects of a nutraceutical cocktail in aged beagles, an established model for human aging and Alzheimer’s disease. The formulation included turmeric extract (curcuminoids), green tea extract (epigallocatechin gallate), N-acetyl cysteine, R-alpha lipoic acid, and black pepper extract (piperine). Over a 3-month period, treated dogs

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June 26, 2025 No Comments

The Role of Antioxidants in the Prevention of Cadmium-Induced Endothelial Dysfunction

This review explores how cadmium (Cd) exposure impairs endothelial function—primarily through oxidative stress—and how antioxidants can mitigate these effects. Cd induces reactive oxygen species (ROS) production, reduces nitric oxide (NO) bioavailability, and disrupts vasodilatory function, contributing to vascular inflammation and hypertension. The article reviews in vitro and in vivo studies

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June 26, 2025 No Comments

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

This review article explores the mechanisms by which cadmium (Cd) induces oxidative stress and evaluates the potential protective roles of natural antioxidants. Cd exposure disrupts cellular redox homeostasis through the excessive generation of reactive oxygen species (ROS), leading to damage in lipids, proteins, and DNA. The review highlights natural antioxidant

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June 26, 2025 No Comments

Stuck at the bench: Potential natural neuroprotective compounds for concussion

This narrative review examines a range of natural compounds with potential neuroprotective effects in the context of concussion and mild traumatic brain injury (mTBI). Preclinical studies suggest that agents such as omega-3 fatty acids, curcumin, resveratrol, and green tea catechins exhibit anti-inflammatory, antioxidant, and neurorestorative properties that could mitigate post-concussive

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June 26, 2025 No Comments

Prostate Cancer Disparity, Chemoprevention, and Treatment by Specific Medicinal Plants

This 2019 review addresses the persistent racial disparities in prostate cancer (PC) incidence and mortality, particularly among African American men. It explores the potential of three medicinal plants—curcumin, garlic (Allium sativum), and Vernonia amygdalina—as chemopreventive and therapeutic agents against PC. These plants have demonstrated anti-cancer properties, including inhibition of cell

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June 26, 2025 No Comments

Recent Progress on Nutraceutical Research in Prostate Cancer

This 2014 review highlights the potential of various nutraceuticals—such as isoflavones, indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM), lycopene, epigallocatechin-3-gallate (EGCG), and curcumin—in the prevention and treatment of prostate cancer (PCa). These compounds have been shown to modulate critical signaling pathways, including androgen receptor (AR), Akt, and NF-κB, which are involved in PCa

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June 26, 2025 No Comments

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

This review article explores the potential of phytochemicals in targeting breast cancer stem cells (BCSCs) and associated signaling pathways. It discusses various plant-derived compounds, such as curcumin, genistein, resveratrol, and sulforaphane, highlighting their mechanisms in inhibiting BCSC proliferation, inducing apoptosis, and modulating key pathways like Wnt/β-catenin, Notch, Hedgehog, and PI3K/Akt/mTOR.

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June 26, 2025 No Comments

Integrating Dietary Supplements into Cancer Care

This 2013 review article examines the use of dietary supplements (DS) in oncology, highlighting that a majority of cancer patients incorporate DS into their treatment regimens. The authors discuss commonly used supplements such as curcumin, glutamine, vitamin D, Maitake mushrooms, fish oil, green tea, milk thistle, Astragalus, melatonin, and probiotics.

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June 26, 2025 No Comments

Melanoma Chemoprevention: Current Status and Future Prospects

This 2017 review evaluates the role of phytochemicals in the chemoprevention of melanoma, discussing their mechanisms in modulating critical molecular pathways such as MAPK, PI3K/AKT, and NF-κB. Compounds like fisetin, EGCG, resveratrol, curcumin, and silymarin are shown to inhibit melanoma cell proliferation, induce apoptosis, and suppress metastasis in preclinical models.

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June 26, 2025 No Comments