Well Referenced

Tag: EGCG

Phytochemicals and regulation of the adipocyte life cycle

This 2008 review article explores the role of various dietary phytochemicals in modulating different stages of the adipocyte life cycle, including preadipocyte proliferation, differentiation (adipogenesis), lipid accumulation, and apoptosis. Compounds such as genistein, conjugated linoleic acid (CLA), docosahexaenoic acid (DHA), epigallocatechin gallate (EGCG), quercetin, resveratrol, and ajoene have been shown

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June 26, 2025 No Comments

Effect of Tea Catechins on Influenza Infection and the Common Cold with a Focus on Epidemiological/Clinical Studies

This 2018 review examines the antiviral properties of tea catechins, particularly epigallocatechin gallate (EGCG), against influenza and common cold viruses. Experimental studies indicate that catechins inhibit viral adsorption, replication, and neuraminidase activity, and enhance immune responses. Epidemiological studies suggest that regular green tea consumption and catechin-based gargling may reduce the

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June 26, 2025 No Comments

Recent Progress on Nutraceutical Research in Prostate Cancer

This 2014 review highlights the potential of various nutraceuticals—such as isoflavones, indole-3-carbinol (I3C), 3,3′-diindolylmethane (DIM), lycopene, epigallocatechin-3-gallate (EGCG), and curcumin—in the prevention and treatment of prostate cancer (PCa). These compounds have been shown to modulate critical signaling pathways, including androgen receptor (AR), Akt, and NF-κB, which are involved in PCa

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June 26, 2025 No Comments

Melanoma Chemoprevention: Current Status and Future Prospects

This 2017 review evaluates the role of phytochemicals in the chemoprevention of melanoma, discussing their mechanisms in modulating critical molecular pathways such as MAPK, PI3K/AKT, and NF-κB. Compounds like fisetin, EGCG, resveratrol, curcumin, and silymarin are shown to inhibit melanoma cell proliferation, induce apoptosis, and suppress metastasis in preclinical models.

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June 26, 2025 No Comments

Phytochemicals for the Management of Melanoma

This 2016 review explores the potential of various dietary phytochemicals in preventing and treating melanoma, emphasizing their low toxicity and public acceptance. Key compounds such as fisetin, epigallocatechin-3-gallate (EGCG), resveratrol, curcumin, proanthocyanidins, silymarin, apigenin, capsaicin, genistein, indole-3-carbinol, and luteolin are highlighted for their ability to modulate multiple signaling pathways involved

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June 26, 2025 No Comments

Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells

This comprehensive review examines the cancer chemopreventive effects of green tea and its primary catechin, (-)-epigallocatechin gallate (EGCG), based on over three decades of research. The first section highlights key findings, including: Delayed Cancer Onset: A 10-year prospective cohort study indicated that women consuming over 10 cups of green tea

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June 26, 2025 No Comments

Epigallocatechin gallate hinders human hepatoma and colon cancer sphere formation

This 2016 study evaluates the inhibitory effects of epigallocatechin gallate (EGCG), a green tea polyphenol, on cancer stem-like cell (CSC) populations derived from human hepatoma and colon cancer cell lines. CSCs were enriched via sphere formation under nonadherent, serum-free conditions and exhibited higher expression of stemness markers, Nek2, and ATP-binding

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June 26, 2025 No Comments

Impact of Antioxidants on the Ability of Phenolic Phytochemicals to Kill HCT116 Colon Cancer Cells

This study investigated how antioxidants affect the cytotoxicity of phenolic phytochemicals, specifically epigallocatechin gallate (EGCG) and curcumin, on HCT116 colon cancer cells. Both compounds induced DNA damage and apoptosis in these cells. However, the presence of antioxidants like ascorbate and N-acetylcysteine (NAC) inhibited EGCG-induced DNA damage and apoptosis, but did

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June 26, 2025 No Comments