Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients

This study examined the effects of supplementing cysteine and glycine—precursors to glutathione (GSH)—in older HIV-infected men with GSH deficiency. Over 14 days, participants received oral cysteine and glycine supplementation, which restored GSH synthesis. As a result, the study reported significant improvements in both fasting and insulin-stimulated mitochondrial fuel oxidation, insulin