Well Referenced

Tag: antioxidant therapy

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin

This 2016 open-label, single-center clinical trial evaluated the efficacy and tolerability of a dual-product regimen comprising a 0.5% encapsulated retinol treatment and a moisturizer containing 30% tetrahexyldecyl ascorbate (vitamin C), along with vitamin E and coenzyme Q10, in 44 women aged 35–60 with mild-to-moderate facial hyperpigmentation and photodamage over 12

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June 26, 2025 No Comments

Protective effect of methylene blue on TNBS-induced colitis in rats mediated through the modulation of inflammatory and apoptotic signalling pathways

This 2019 study investigated the therapeutic potential of methylene blue (MB) in a rat model of trinitrobenzene sulfonic acid (TNBS)-induced colitis, simulating ulcerative colitis. MB was administered intraperitoneally at doses of 1, 2, and 4 mg/kg, compared to a control group receiving sulfasalazine (500 mg/kg orally). MB treatment resulted in

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June 26, 2025 No Comments

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

This 2017 study evaluated methylene blue (MB) as a potential anti-aging agent for human skin. MB demonstrated potent reactive oxygen species (ROS) scavenging in cultured human skin fibroblasts from both healthy donors and progeria patients. Compared to other antioxidants like N-Acetyl-L-Cysteine (NAC), MitoQ, and MitoTEMPO, MB more effectively stimulated fibroblast

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June 26, 2025 No Comments

The benefits of ascorbate to protect healthy cells in the prevention and treatment of oncological diseases

This review explores the protective role of ascorbate (vitamin C) in oncology, emphasizing its antioxidant properties that safeguard healthy cells from oxidative stress induced by internal and external factors, including chemotherapy and radiotherapy. Ascorbate neutralizes reactive oxygen species, thereby preventing mitochondrial and DNA damage, and modulates immune responses to support

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June 26, 2025 No Comments

Intravenous Vitamin C in the Treatment of Shingles: Results of a Multicenter Prospective Cohort Study

This multicenter prospective cohort study evaluated the efficacy and safety of intravenous vitamin C (IVC) in treating shingles (herpes zoster). Sixty-seven patients received IVC (7.5 g per infusion) over approximately two weeks. Results indicated significant reductions in pain and dermatological symptoms, with a lower incidence of post-herpetic neuralgia (PHN) compared

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June 26, 2025 No Comments

Treatment for Diabetic Mononeuropathy with Alpha-Lipoic Acid

This clinical study evaluated the efficacy of alpha-lipoic acid (ALA) in treating diabetic mononeuropathy. Patients received 600 mg of ALA intravenously daily for 10 days, followed by 600 mg orally daily for approximately 69 days. Results demonstrated significant symptom improvement: total symptom scores decreased by an average of 2.7 points

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June 26, 2025 No Comments

The Role of Natural Antioxidants Against Reactive Oxygen Species Produced by Cadmium Toxicity: A Review

This review article explores the mechanisms by which cadmium (Cd) induces oxidative stress and evaluates the potential protective roles of natural antioxidants. Cd exposure disrupts cellular redox homeostasis through the excessive generation of reactive oxygen species (ROS), leading to damage in lipids, proteins, and DNA. The review highlights natural antioxidant

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June 26, 2025 No Comments