This 2018 review article published in Frontiers in Immunology (DOI: 10.3389/fimmu.2018.00586, PMID: 29686666) explores the role of inflammation and cytokine dysregulation in aging and age-related diseases. The review focuses on how cytokines like TNF-α, IL-6, and IL-1β contribute to chronic low-grade inflammation, which accelerates the development of neurodegenerative diseases, cardiovascular