Well Referenced

Tag: TNF-α

Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial

This Phase II randomized, double-blind, placebo-controlled trial assessed the safety and efficacy of intravenous allogeneic human mesenchymal stem cells (allo-hMSCs) in 30 elderly patients (mean age 75.5 years) with aging frailty. Participants received either 100 million or 200 million allo-hMSCs or placebo. No treatment-related serious adverse events were observed. The

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June 26, 2025 No Comments

The acute effects of preoperative ozone therapy on surgical wound healing

This 2016 animal study assessed the impact of preoperative rectal ozone insufflation on surgical wound healing in rabbits. Twenty-one rabbits were divided into three groups: sham, surgical wound without treatment, and surgical wound with ozone therapy (70 µg/mL O₂-O₃ mixture, 12 mL, administered rectally every other day for six sessions).

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June 26, 2025 No Comments

Effects of Alpha-Lipoic Acid Supplementation on Inflammatory Biomarkers and Matrix Metalloproteinase-3 in Rheumatoid Arthritis Patients

This 2015 randomized, double-blind, placebo-controlled clinical trial evaluated the effects of 8-week supplementation with 1200 mg/day alpha-lipoic acid (ALA) on inflammatory biomarkers and matrix metalloproteinase-3 (MMP-3) in 70 women with rheumatoid arthritis (RA). Participants were assessed for serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6),

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June 26, 2025 No Comments

Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients

This 2022 randomized, double-blind, placebo-controlled trial investigated the effects of alpha-lipoic acid (ALA) in reducing chemotherapy-induced toxicities in 64 women with breast cancer undergoing treatment with doxorubicin, cyclophosphamide, and paclitaxel. Patients were assigned to receive either ALA (600 mg/day) or placebo for six months. ALA significantly improved chemotherapy-induced peripheral neuropathy

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June 26, 2025 No Comments

Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress

This animal study investigated the effects of two plant extract combinations, Antistress I and Antistress II, on cytokine levels in rats exposed to acute and chronic stress. The results showed that both combinations reduced pro-inflammatory cytokines (TNF-α and IL-6) and modulated the anti-inflammatory cytokine IL-10, with Antistress II having the

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June 26, 2025 No Comments

Natural Compound Resveratrol Attenuates TNF-Alpha-Induced Vascular Dysfunction in Mice and Human Endothelial Cells: The Involvement of the NF-κB Signaling Pathway

This study explored how resveratrol, a natural polyphenol, protects against TNF-α-induced vascular inflammation in human endothelial cells and mice. At physiologically relevant concentrations (as low as 1 μM), resveratrol significantly reduced monocyte adhesion, lowered expression of key inflammatory markers like MCP-1/CCL2 and ICAM-1, and inhibited NF-κB pathway activation. In mice,

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June 26, 2025 No Comments

Quercetin inhibits expression of inflammatory cytokines through attenuation of NF-kappaB and p38 MAPK in HMC-1 human mast cell line

This in vitro study investigated the effects of quercetin on human mast cells (HMC-1) stimulated to produce inflammatory cytokines. The researchers found that quercetin significantly inhibited the expression and production of TNF-α, IL-1β, IL-6, and IL-8 by attenuating the activation of NF-kappaB and p38 MAPK pathways—two major regulators of inflammation.

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June 26, 2025 No Comments

Gut microbiota, microinflammation, metabolic profile, and zonulin concentration in obese and normal weight subjects

This observational study found that obese individuals had higher plasma zonulin levels, which were positively correlated with inflammatory markers (e.g., TNF-α, IL-6), body mass, BMI, and glucose levels, and inversely correlated with dietary protein intake. Increased intestinal permeability, as indicated by elevated zonulin levels, may play a role in the

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June 26, 2025 No Comments

Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism?

This observational study examined 103 women who recently completed early-stage breast cancer treatment, finding that over 60% experienced fatigue and sleep disturbances, and 25% showed elevated depressive symptoms. Chemotherapy was associated with higher levels of fatigue, sleep problems, depressive symptoms, and increased levels of the inflammatory marker sTNF-RII (all P

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June 26, 2025 No Comments

Proinflammatory cytokines, aging, and age-related diseases

This 2013 review article published in the Journal of the American Medical Directors Association (PMID: 23792036) explores the role of proinflammatory cytokines—such as IL-6, IL-1, TNF-α, and CRP—in aging and their link to age-related diseases. Chronic low-grade inflammation, termed “inflamm-aging,” is associated with increased frailty, sarcopenia, cardiovascular conditions, and neurodegenerative

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June 26, 2025 No Comments